WormMine: ExpressionPattern Expr2860

• Pattern: Expression of UNC-122 was observed in body wall muscle and coelomocytes.
• Primary Identifier: Expr2860
• Subcellular Localization: Antibody staining against the vesicular acetylcholine transporters UNC-17 and epitope-tagged acetylcholine receptors (UNC-29 and UNC-38) showed that UNC-122 clusters precisely oppose UNC-17 clusters, consistent with the localization of UNC-122 to muscle endplates. UNC-122 clusters do not precisely overlap but rather interdigitate with clusters of UNC-38 AChR or UNC-29; the relatively large size of muscle endplates suggests that UNC-122 and UNC-38 may localize to distinct subdomains within muscle end-plates. Together with the demonstration of a muscular focus of action of unc-122, authors conclude from these localization experiments that UNC-122 localizes to the postsynaptic side of NMJs. Epitope-tagged UNC-122 shows a punctate localization along the ventral nerve cord (VNC). These sites do not coincide with muscle-hypodermis attachment sites, as observed by antibody costaining against an attachment marker protein.

2 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion.	body wall musculature	body muscle	WBbt:0005813
A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles.	coelomocyte		WBbt:0005751

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006845	unc-122	F11C3.2	Caenorhabditis elegans

0 Life Stages