WormMine: ExpressionPattern Expr1050

• Pattern: UNC-130 is expressed strongly in embryos and in L1 larvae. Expression is severely reduced or absent in later larval and adult stages. Embryonic expression is first observed at about the 60-cell stage, when it is expressed in the nuclei of four cells. As embryogenesis continues, UNC-130 becomes more broadly expressed in several cell types. Double-stained embryos with antibodies against the LIN-26 protein that stain hypodermal cells found strong UNC-130 expression in the ABp(l/r)aapapa cells, which give rise to the AWA and ASG neurons. At this developmental stage, UNC-130 is also expressed in several other neuronal precursors including the ABp(l/r)aapapp cells, which are the precursors to the AIB interneurons and the ASI chemosensory neurons. In addition, UNC-130 is expressed in other cell types, including the hypodermal cells hyp4, hyp5, hyp6, hyp7, H0, and H1, as determined by colocalization with LIN-26 antibodies. Colocalization of UNC-130 with ODR-7 and tax-2::GFP in wild-type animals failed to observe colocalization of UNC-130 with either of these markers.
• Primary Identifier: Expr1050
• Subcellular Localization: UNC-130 is localized to the nuclei of all expressing cells.

11 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
entire syncytium of hyp7	hyp7 syncytium	hyp7	WBbt:0005734
Cylindrical hypodermal syncytium in head	hyp5	lineage name: ABarpappap	WBbt:0004685
Cylindrical hypodermal syncytium in head	hyp4	lineage name: ABarpapapa	WBbt:0004687
Seam hypodermal cell, postembryonic blast cell	H1L	lineage name: ABplaaappp	WBbt:0004766
Seam hypodermal cell, postembryonic blast cell	H1R	lineage name: ABarpapppp	WBbt:0004765
Cylindrical hypodermal syncytium in head	hyp6	lineage name: ABarpaapaa	WBbt:0004679
embryonic cell	ABpraapapa		WBbt:0005872
Hook sensory neurons.	HO neuron		WBbt:0005177
embryonic cell	ABplaapapa		WBbt:0006120
embryonic cell	ABpraapapp		WBbt:0006530
embryonic cell	ABplaapapp		WBbt:0006586

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006853	unc-130	C47G2.2	Caenorhabditis elegans

5 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024
	The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.		fully-elongated embryo Ce	WBls:0000021
	The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over.		elongating embryo Ce	WBls:0000015
	The C. elegans life stage spanning 290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastrulation and is enclosing.		enclosing embryo Ce	WBls:0000013
	The C. elegans life stage spanning 100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation.		gastrulating embryo Ce	WBls:0000010