WormMine: AnatomyTerm WBbt:0004872

• Definition: Ventral cord motor neuron, innervates ventral body muscles
• Name: VA1
• Primary Identifier: WBbt:0004872
• Synonym: lineage name: W.pa

1 Children

Definition	Name	Synonym	Primary Identifier
nucleus of pedigree W.pa	W.pa nucleus		WBbt:0003206

7 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts enriched in VA1 according to single cell RNAseq.	Genes that pass the Bonferroni threshold for multiple comparisons (q < 0.05) are significantly enriched.	WBPaper00066550:VA1_enriched
	Single-cell RNA-Seq cell group 6_3 expressed in neuron.	scVI 0.6.0	WBPaper00065841:6_3
	Single-cell RNA-Seq cell group 6_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:6_0
	Single-cell RNA-Seq cell group 14_2 expressed in neuron.	scVI 0.6.0	WBPaper00065841:14_2
	Single-cell RNA-Seq cell group 14_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:14_0
	Single-cell RNA-Seq cell group 14_1 expressed in neuron.	scVI 0.6.0	WBPaper00065841:14_1
	Transcripts enriched in VA according to single cell RNAseq.	Genes that pass the Bonferroni threshold for multiple comparisons (q < 0.05) are significantly enriched.	WBPaper00061651:VA_enriched

28 Expression Patterns

• Primary Identifier: Expr15649

• Primary Identifier: Expr15558

• Primary Identifier: Expr15567

• Primary Identifier: Expr15571

• Primary Identifier: Expr15572

• Primary Identifier: Expr15573

• Primary Identifier: Expr15579

• Primary Identifier: Expr15586

• Primary Identifier: Expr15651

• Primary Identifier: Expr15652

• Primary Identifier: Expr15589

• Primary Identifier: Expr15591

• Primary Identifier: Expr15598

• Primary Identifier: Expr15604

• Primary Identifier: Expr14590
• Pattern: Embryonic expression of exc-7 was first observed at the bean stage. By reverse lineaging with use of SIMI-Biocell software, we confirm the identity of one of the expressing cells at this stage as the excretory canal cell. In L1 animals, broad expression in the head, ventral nerve cord (VNC), and tail was observed. In young adults, expression is notably observed in vulva cells. In the nervous system specifically, expression is observed in many neurons throughout the body, but unlike Drosophila Elav, exc-7::gfp it is not panneuronally expressed. We confirmed previously reported expression in cholinergic VNC MNs, but absence of GABAergic VNC MNs, consistent with previous reports (Fujita et al., 1999; Loria et al., 2003) and consistent with exc-7 functioning in cholinergic, but not GABAergic neurons to control alternative splicing (Norris et al., 2014). exc-7::gfp is also expressed in some non-neuronal cell types, including muscle and hypodermis, but not in the gut. A previous report showed that exc-7 is only transiently and weakly expressed in the excretory cell, which, based on exc-7's excretory mutant phenotype, has puzzled researchers (Fujita et al., 2003). We find that the gfp tagged exc-7 locus is strongly and continuously expressed in the excretory canal cell.

• Primary Identifier: Expr15608

• Primary Identifier: Expr15611

• Primary Identifier: Expr15570

• Primary Identifier: Expr15644

• Primary Identifier: Expr12716

• Primary Identifier: Expr12717

• Primary Identifier: Expr15633

• Primary Identifier: Expr12715

• Primary Identifier: Expr15314

• Primary Identifier: Expr10750
• Pattern: The expression pattern of lhIs35[Punc::55::gfp] was similar to previous observations (Zhou and Walthall, 1998) except that VD precursor cells were also labeled. GFP was detected in the 13 VD neurons, 11 AS neurons, VA1 and PDB. Punc-55 activity was highest during L2, and was not detected beyond L4, as reported (Zhou and Walthall, 1998).

• Primary Identifier: Expr15643

• Primary Identifier: Expr13466
• Pattern: Onset of expression: VA1-VA11: late L2; VB1-VB11: early L2; SABVL/R: 3-fold embryo.

• Primary Identifier: Expr13469
• Pattern: Onset of expression: VA1-VA12, VB2- VB11, SABVL/R: late L1.

0 Life Stages

3 Parents

Definition	Name	Synonym	Primary Identifier
Neuron class of twelve motoneurons, distributed along the ventral cord, which innervate ventral body muscles.	VA neuron		WBbt:0005339
neuron whose cell body is in the retrovesicular ganglion.	retrovesicular ganglion neuron	retrovesicular ganglion	WBbt:0005403
post-embryonic cell of pedigree W.p	W.p		WBbt:0007571