WormMine: ExpressionPattern Expr13561

• Pattern: hpk-1 is expressed broadly during embryogenesis, but becomes more restricted in expression during larval development. L3-stage larvae display robust expression of the GFP fusion in many head and motor neurons, and lower levels of expression in the intestine and the seam cells of the hypodermis. By late L4 stage, GFP expression is largely restricted to neurons, and is maintained in nerve cells of the head and nerve cord during adulthood, congruent with a previous study.
• Primary Identifier: Expr13561
• Subcellular Localization: Localization of HPK-1:: GFP protein is most concentrated in the nucleus often within distinct sub-nuclear sites. HPK-1 co-localizes with HSF-1 at the subcellular level.

6 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
a cellular object that consists of subcellular components, expresses genes or functions.	Cell	Cell type	WBbt:0004017
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679
a group of hypodermal cells that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail	seam cell	lateral hypodermis	WBbt:0005753
neuron making synapse on an effector (muscle, gland).	motor neuron	motoneuron	WBbt:0005409

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001994	hpk-1	F20B6.8	Caenorhabditis elegans

4 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003