WormMine: ExpressionPattern Expr13247

• Pattern: The twk-7 promoter drives DsRed reporter expression in some head and tail neurons as well as in all A-, B-, and AS-type motor neurons of the ventral nerve cord. In addition, DsRed expression was seen in GFP negative neurons. According to their number and stereotypic position, these TWK-7-expressing cells were identified as the 13 ventral and 6 dorsal GABAergic D-type motor neurons of the ventral nerve cord. The cell-type-specific expression pattern of TWK-7 was confirmed in worms that express a C-terminal tagged TWK-7::mCherry fusion protein under the control of the twk-7 promoter. TWK-7::mCherry was localized along the ventral nerve cord and in punctated structures in the soma of motor neurons. Taken together, in accordance with the unraveled impact of TWK-7 on locomotor activity of C. elegans, TWK-7 is expressed in all types of motor neurons of the ventral nerve cord that control body-wall muscle activity. The twk-7 promoter drives DsRed reporter expression in some head and tail neurons as well as in all A-, B-, and AS-type motor neurons of the ventral nerve cord. In addition, DsRed expression was seen in GFP2 neurons. According to their number and stereotypic position, these TWK-7-expressing cells were identified as the 13 ventral and 6 dorsal GABAergic D-type motor neurons of the ventral nerve cord. The cell-type-specific expression pattern of TWK-7 was confirmed in worms that express a C-terminal tagged TWK-7::mCherry fusion protein under the control of the twk-7 promoter. TWK-7::mCherry was localized along the ventral nerve cord and in punctated structures in the soma of motor neurons. Taken together, in accordance with the unraveled impact of TWK-7 on locomotor activity of C. elegans, TWK-7 is expressed in all types of motor neurons of the ventral nerve cord that control body-wall muscle activity.
• Primary Identifier: Expr13247

8 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring.	ventral nerve cord	ventral cord	WBbt:0005829
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
Neuron class of eleven motoneurons, distributed along the ventral cord, which innervate ventral body muscles.	VB neuron		WBbt:0005336
Neuron class of nine ventral cord motor neuron, innervates dorsal muscle.	DA neuron		WBbt:0005278
Neuron class of seven motoneurons that innervate dorsal muscles and have cell bodies in the ventral cord.	DB neuron		WBbt:0005274
Neuron class of twelve motoneurons, distributed along the ventral cord, which innervate ventral body muscles.	VA neuron		WBbt:0005339
Neuron class of eleven motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles.	AS neuron		WBbt:0005334
neuron with its cell body situated in the tail, posterior to rectum.	tail neuron		WBbt:0006759

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006662	twk-7	F22B7.7	Caenorhabditis elegans

0 Life Stages