WormMine: LifeStage WBls:0000682

• Definition: The Strongyloides life-cycle stage in which male and female adult worms reproduce sexually and live entirely outside a host organism.
• Primary Identifier: WBls:0000682
• Public Name: Strongyloides free-living adult

0 Anatomy Terms

1 Contained In

Remark	Definition	Other Name	Public Name	Primary Identifier
	The nematode life-stage that begins when the organism is fully-developed and has reached maturity.		nematode adult	WBls:0000104

6 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
parasitic vs free-living.	Transcripts that showed significantly increased expression at parasitic female stage (collected from S. ratti-infected rats), comparing to free living female stage.	Differentially expressed genes in all pairwise comparisons (parasitic vs. free-living; parasitic vs. iL3; and iL3 vs. free-living) were determined for S.ratti and S.stercoralis using the R (version 3.1.2) package edgeR version 3.6.8. Genes with less than one count per million reads were excluded. Genes were considered to be differentially expressed if the false discovery rate (FDR) was <= 0.001 and the fold change was >= 2.	WBPaper00050919:up_parasitic_vs_free-living_mRNA
parasitic vs free-living.	Transcripts that showed significantly increased expression at infective third-stage larva stage, comparing to free living female stage.	Differentially expressed genes in all pairwise comparisons (parasitic vs. free-living; parasitic vs. iL3; and iL3 vs. free-living) were determined for S.ratti and S.stercoralis using the R (version 3.1.2) package edgeR version 3.6.8. Genes with less than one count per million reads were excluded. Genes were considered to be differentially expressed if the false discovery rate (FDR) was <= 0.001 and the fold change was >= 2.	WBPaper00050919:up_infective-L3_vs_free-living_mRNA
parasitic vs free-living.	Transcripts that showed significantly decreased expression at infective third-stage larva stage, comparing to free living female stage.	Differentially expressed genes in all pairwise comparisons (parasitic vs. free-living; parasitic vs. iL3; and iL3 vs. free-living) were determined for S.ratti and S.stercoralis using the R (version 3.1.2) package edgeR version 3.6.8. Genes with less than one count per million reads were excluded. Genes were considered to be differentially expressed if the false discovery rate (FDR) was <= 0.001 and the fold change was >= 2.	WBPaper00050919:down_infective-L3_vs_free-living_mRNA
parasitic vs free-living.	Transcripts that showed significantly decreased expression at parasitic female stage (collected from S. ratti-infected rats), comparing to free living female stage.	Differentially expressed genes in all pairwise comparisons (parasitic vs. free-living; parasitic vs. iL3; and iL3 vs. free-living) were determined for S.ratti and S.stercoralis using the R (version 3.1.2) package edgeR version 3.6.8. Genes with less than one count per million reads were excluded. Genes were considered to be differentially expressed if the false discovery rate (FDR) was <= 0.001 and the fold change was >= 2.	WBPaper00050919:down_parasitic_vs_free-living_mRNA
parasitic vs free-living.	Proteins that showed significantly decreased expression at parasitic female stage (collected from S. ratti-infected rats), comparing to free living female stage.	Significant differences were analyzed statistically by ANOVA. Q-values are adjusted P values and were calculated by Progenesis based on an optimized false discovery (FDR) approach. A protein was considered to be differentially expressed if q < 0.05.	WBPaper00050919:down_parasitic_vs_free-living_protein
parasitic vs free-living.	Proteins that showed significantly increased expression at parasitic female stage (collected from S. ratti-infected rats), comparing to free living female stage.	Significant differences were analyzed statistically by ANOVA. Q-values are adjusted P values and were calculated by Progenesis based on an optimized false discovery (FDR) approach. A protein was considered to be differentially expressed if q < 0.05.	WBPaper00050919:up_parasitic_vs_free-living_protein

0 Expression Patterns

0 Followed By

0 Preceded By

2 Sub Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	Adult female Strongyloides living entirely outside of a host or vector organism.		Strongyloides free living adult female	WBls:0000729
	Adult male Strongyloides living entirely outside of a host or vector organism.		Strongyloides free living adult male	WBls:0000742