WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00038541 Phenotype Remark  The pharynxes of lat-1 RNAi animals were also resistant to emodepside and continued to pump at concentrations up to 100 nM emodepside (IC50 = 70 nm for lat-1 RNAi compared with 4.1 nm for wild-type animals).
Remark  lat-1 RNAi animals had a prolonged pharyngeal pump duration compared to wild-type (225 +-23 ms (n=21) for lat-1 RNAi compared with a wild-type duration of 162 +- 16 ms (n=22)). The pharynxes of lat-1 RNAi animals were also resistant to emodepside and continued to pump at concentrations up to 100 nM emodepside (IC50 = 70 nm for lat-1 RNAi compared with 4.1 nm for wild-type animals).
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1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00002251 lat-1 B0457.1 Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:B0457.1a B0457.1a 3045   II: 8896879-8896987
CDS:B0457.1b B0457.1b 3039   II: 8896879-8896987
CDS:B0457.1c B0457.1c 345   II: 8896879-8896987

0 Laboratories

2 Phenotype

Identifier Name Description
WBPhenotype:0000634 pharyngeal pumping variant Any variation in the contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes compared to control.
WBPhenotype:0001006 pharyngeal pumping rate variant The number of coordinated contraction-relaxation cycles (pumps) exhibited by the pharyngeal muscle deviates from that observed for control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00024348

1 Strain

WormBase ID
WBStrain00028995