WormMine: RNAi WBRNAi00097530

• WormBase ID: WBRNAi00097530
• Genotype: ced-5(n1812); opIs117[Phsp::sel-1sp::GFP::AnxV] (opIs117 is a marker for phospholipid bilayer outer leaflet phosphatidylserine (PS) exposure, an indicator of apoptosis)
• Phenotype Remark: RNAi results in an increase in the number of apoptotic germ cell corpses, as determined by Nomarski/DIC optics (for germ cell corpses). GFP epifluorescence (for phosphatidylserine exposure labeled by GFP::AnxV) was not increased by tat-1 RNAi, indicating a decoupling of apoptosis from phosphatidylserine exposure at the plasma membrane outer leaflet.
• Remark: (Figure 3B, S2B) tat-1 RNAi. Curator cannot reconcile author statement as to sequence used; curating with first 800 bp of clone yk34c11

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00013034	tat-1	Y49E10.11	Caenorhabditis elegans

3 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y49E10.11a	Y49E10.11a	3420	III: 12399363-12399460
CDS:Y49E10.11b	Y49E10.11b	3270	III: 12404132-12404204
CDS:Y49E10.11c	Y49E10.11c	3579	III: 12401682-12402063

1 Laboratories

Primary Identifier
WS

2 Phenotype

Identifier	Name	Description
WBPhenotype:0000730	apoptosis variant	Animals exhibit variations in any processes that influence the programmed cell death pathway. Induction of the apoptotic pathway triggers the activity of proteolytic caspases, which in turn lead to the destruction of the cell.
WBPhenotype:0000241	accumulated cell corpses	Animals exhibit an increase in the quantity of cells that have undergone programmed cell death but have not been engulfed.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00030738

0 Strain