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Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO
Namespace  molecular_function Obsolete  false
Description  A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
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0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

19 Ontology Annotations

Annotation Extension Qualifier
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has_input(WB:WBGene00019282) enables
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50 Parents

Identifier Name Description
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0060255 regulation of macromolecule metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0080090 regulation of primary metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0019219 regulation of nucleobase-containing compound metabolic process Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0003676 nucleic acid binding Binding to a nucleic acid.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0048523 negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043228 membraneless organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0043232 intracellular membraneless organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0006357 regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
GO:0000122 negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
GO:0045892 negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0009890 negative regulation of biosynthetic process Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
GO:0009892 negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0010468 regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
GO:0009889 regulation of biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
GO:0045934 negative regulation of nucleobase-containing compound metabolic process Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:2001141 regulation of RNA biosynthetic process Any process that modulates the frequency, rate or extent of RNA biosynthetic process.
GO:0051252 regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.

53 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0000981 GO:0001227
is_a GO:0140110 GO:0001227
is_a GO:0001217 GO:0001227
part of GO:0000122 GO:0001227
part of GO:0000122 GO:0001227
has part GO:0000977 GO:0001227
has part GO:0000976 GO:0001227
has part GO:0000977 GO:0001227
occurs in GO:0043232 GO:0001227
part of GO:0010558 GO:0001227
part of GO:0009889 GO:0001227
part of GO:0010556 GO:0001227
part of GO:0008150 GO:0001227
part of GO:2001141 GO:0001227
occurs in GO:0000785 GO:0001227
is_a GO:0003700 GO:0001227
occurs in GO:0110165 GO:0001227
part of GO:0045892 GO:0001227
has part GO:0003690 GO:0001227
part of GO:0045934 GO:0001227
part of GO:0009890 GO:0001227
part of GO:1902679 GO:0001227
part of GO:0060255 GO:0001227
part of GO:0009892 GO:0001227
part of GO:0048523 GO:0001227
part of GO:0010468 GO:0001227
part of GO:0051253 GO:0001227
part of GO:0051252 GO:0001227
occurs in GO:0005575 GO:0001227
occurs in GO:0005694 GO:0001227

18 Synonyms

Name Type
RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding synonym
RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding synonym
transcriptional repressor activity, metal ion regulated sequence-specific DNA binding synonym
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription synonym
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding synonym
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding synonym
GO:0001078 alt_id
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding synonym
GO:0001210 alt_id
GO:0001206 alt_id
GO:0001214 alt_id
distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific synonym
metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription synonym
metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription synonym
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription synonym
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific synonym
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription synonym
RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription synonym