WormMine: ExpressionPattern Expr8783

• Pattern: Nuclear expression of VRK-1::GFP was observed in neurons and hypodermal cells in the head, VNC and tail of C. elegans larvae. Strong expression was also detected in all VPCs. At the L3 larval stage expression was highest in the primary fated vulva cell P6.p and its descendants. At L4 stage, VRK-1::GFP was expressed at equal levels in all 22 nuclei. One of the two transgenic strains showed additional but very weak VRK-1::GFP expression in some uterine cells. Expression was never observed in the AC with any of the two strains.
• Primary Identifier: Expr8783
• Remark: Picture: Fig 3, Fig S2.
• Subcellular Localization: During division of VPCs, VRK-1::GFP was nuclear during interphase but relocated to the nuclear periphery immediately before cell division. During mitosis the protein was bound to chromatin.

10 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring.	ventral nerve cord	ventral cord	WBbt:0005829
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679
	P6.p hermaphrodite		WBbt:0008125
descendent cell of post-embryonic blast cell P5, posterior, in hermaphrodite.	P5.p hermaphrodite		WBbt:0008121
descendent cell of post-embryonic blast cell P4, posterior, in hermaphrodite.	P4.p hermaphrodite		WBbt:0008117
descendent cell of post-embryonic blast cell P3, posterior in hermaphrodite.	P3.p hermaphrodite		WBbt:0008112
	P8.p hermaphrodite		WBbt:0008133
	P7.p hermaphrodite		WBbt:0008129
toroidal epithelial cell that make up the bulk of the uterus, four cells anterior and four cells posterior to the vulva.	uterine toroidal epithelial cell	ut cell	WBbt:0006784

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00017895	vrk-1	F28B12.3	Caenorhabditis elegans

5 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024