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WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  Apart from cells in the neuroblast lineage that generate ASE, nhr-67::mCherry was expressed in multiple other neuroblast lineages in the developing embryo. Expression was usually observed in the grandmother or mother of a neuron, but not earlier. Within the ASEL and ASER-generating lineage branches, nhr-67 was expressed in neuroblasts that generate closely or distantly related cousins of ASEL and ASER. For example, the sister neuroblast of the ASE-generating neuroblast creates the AUA and ASJ neurons and it expressed nhr-67. The cousin of the ASE-mother cell generates the AWB and ADF sensory neurons. nhr-67 was expressed in these cells. In late stage embryos, a few other, postmitotic neurons started to express nhr-67. Embryonic nhr-67 expression was not restricted to the nervous system, but was observed in a small subset of mesodermal and hypodermal cells. No expression was detected in endodermal cells or the germ line. nhr-67 was expressed in the excretory canal cell. Postembryonically, nhr-67 expression persisted only in a few neurons in the head ganglia until the first larval stage and faded shortly thereafter in most, but not all, of these neurons, with expression persisting through adulthood only in the CEPD/V, RMED/V, AVL and RIS neurons. During mid-larval development, nhr-67 was transiently and dynamically expressed in the AC cells of the vulva. Expression was also found in the VU cells and somatic gonad, but not in vulA, vulB or vulC. Within the ASEL/R generating lineages, nhr-67::mCherry was first observed in the grandmother cells of ASEL and ASER. Transgenic animals that co-express a functional nhr-67::mCherry reporter and a functional che-1::yfp reporter revealed that nhr-67 precedes che-1 expression. nhr-67 expression was maintained in the ASEL and ASER neurons until the first larval stage after which it became undetectable, whereas che-1 expression was maintained throughout the life of the animal. In spite of its genetically deduced role in asymmetric gene expression in ASEL and ASER, nhr-67 expression is bilaterally symmetric in ASEL and ASER. Primary Identifier  Expr8786
Remark  Picture: Fig 6.
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51 Anatomy Terms

Definition Name Synonym Primary Identifier
Epidermal layer. hypodermis epidermis WBbt:0005733
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASGL lineage name: ABplaapapap WBbt:0003892
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASGR lineage name: ABpraapapap WBbt:0003891
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASEL lineage name: ABalppppppaa WBbt:0003904
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil ASER lineage name: ABpraaapppaa WBbt:0003903
H-shaped cell associated with the excretory system, largest cell in C. elegans. excretory cell excretory canal cell WBbt:0005812
A blast cell from which a neuron develops. neuroblast   WBbt:0008594
Amphid neuron, prob. chemosensory ADFL lineage name: ABalpppppaa WBbt:0004003
Amphid neuron, prob. chemosensory ADFR lineage name: ABpraaappaa WBbt:0003999
Four processes (canals) of the excretory canal cell each contain a central collecting lumen which feeds to a central lumenal canal in the cell body; the central canal forms a specialized membrane to release fluids into the excretory duct. These five canals form a continuous H-shaped channel which extends almost the full length of the body, generally in contact with the lateral hypodermis and the pseudocoelom. excretory canal canal WBbt:0005775
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWBL lineage name: ABalpppppap WBbt:0003829
Amphid wing cells, neurons having ciliated sheet-like sensory endings closely associated with amphid sheath AWBR lineage name: ABpraaappap WBbt:0003828
anchor cell, induces vulva, part of hermaphrodite gonad. anchor cell AC WBbt:0004522
organ producing either sperm or ova. gonad   WBbt:0005175
Intestino-rectal valve virL lineage name: ABprpappppp WBbt:0004511
Intestino-rectal valve virR lineage name: ABprpappppa WBbt:0004510
Ventral cord motor neurons, innervate dorsal muscles DB4 lineage name: ABprpappapp WBbt:0004843
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha AVAL lineage name: ABalppaaapa WBbt:0003870
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha AVAR lineage name: ABalaappapa WBbt:0003869
Cephalic neurons, contain dopamine CEPDR lineage name: ABarpapaappa WBbt:0004937
Cephalic neurons, contain dopamine CEPVL lineage name: ABplpaappppa WBbt:0004933
Cephalic neurons, contain dopamine CEPVR lineage name: ABprpaappppa WBbt:0004931
Cephalic neurons, contain dopamine CEPDL lineage name: ABplaaaaappa WBbt:0004938
Neuron class of one ring interneuron, cell body in dorsorectal ganglion, has a large vesicle-filled process in ring. DVA lineage name: ABprppppapp WBbt:0004823
Neuron class of one ring and ventral cord interneuron, few synapses. AVL lineage name: ABprpappaap WBbt:0003843
Ring motor neuron RMED lineage name: ABalapppaap WBbt:0005027
Ring motor neuron RMEV lineage name: ABplpappaaa WBbt:0005021
Neuron class of one ring interneuron. RIS lineage name: ABprpappapa WBbt:0005045
Quadrant outer labial socket OLQsoVL lineage name: ABalppaaapp WBbt:0004424
Quadrant outer labial socket OLQsoVR lineage name: ABalaappapp WBbt:0004423

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003657 nhr-67 C08F8.8 Caenorhabditis elegans

6 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The stage that begins when a C.elegans individual is fully-developed and has reached maturity. adult Ce WBls:0000041
  The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch. L3 larva Ce WBls:0000035
  The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch. L2 larva Ce WBls:0000027
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038
  The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch. L1 larva Ce WBls:0000024
  The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching. embryo Ce WBls:0000003