WormMine: ExpressionPattern Expr1329

• Pattern: UNC-42 expression was detected with a mouse antiserum in several cells as early as 260 minutes of embryogenesis and in neurons at high levels in the head by comma stage, the time when these neurons extend axons and establish connections. Expression in head neurons continues into adulthood. UNC-42 was strongly expressed in at least 20 pairs of neurons of the head, including the AVA, AVD and AVE interneurons, ASH sensory neurons, and RMD and SMB motor neurons. Other neurons that express high levels of UNC-42 include the AIN, AVH, AVJ, AVK, RIV, SAA and SIB interneurons. The same expression pattern in the head was detected in animals that carry a transgene that encodes an UNC-42 protein tagged at its C terminus with GFP(gmEx186). Antiserum to UNC-42 and the gmEx104 GFP reporter gene revealed low levels of unc-42 expression in hypodermis and additional neurons in the head. Transient expression of UNC-42 protein was also detected in the DD motor neurons at hatching and at low levels in postembryonic ventral cord motor neurons derived from P11. UNC-42 protein was not detected in descendants of P2-P10 or P12. In the tail, unc-42-gfp (gmEx104) is strongly expressed in PVT.
• Primary Identifier: Expr1329

40 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
neuron with cell body associated with the ventral nerve cord.	ventral cord neuron	ventral cord motoneuron	WBbt:0005300
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
Neuron class of one interneuron, projects along ventral cord to ring.	PVT	lineage name: ABplpappppa	WBbt:0004070
Neuron class of six motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles. Each cell has a short, posteriorly directed and a longer, anteriorly directed process emanating from its cell body. The anterior process has a branch, which leaves the ventral cord as a commissure and runs round to the dorsal cord.	DD neuron		WBbt:0005270
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil	ASHL	lineage name: ABplpaappaa	WBbt:0003890
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil	ASHR	lineage name: ABprpaappaa	WBbt:0003889
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally	SIBDL	lineage name: ABplppaaaaa	WBbt:0004981
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha	AVAL	lineage name: ABalppaaapa	WBbt:0003870
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally	SIBDR	lineage name: ABprppaaaaa	WBbt:0004979
Ventral cord interneuron, synapses onto VA, DA, and AS motor neurons; formerly called alpha	AVAR	lineage name: ABalaappapa	WBbt:0003869
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally	SIBVL	lineage name: ABplpapaapp	WBbt:0004978
Receives a few synapses in the ring, has a posteriorly directed process that runs sublaterally	SIBVR	lineage name: ABprpapaapp	WBbt:0004977
Ring interneuron, anteriorly projecting process that runs sublaterally	SAAVR	lineage name: ABprpaaaaaa	WBbt:0005001
Ring interneuron, anteriorly projecting process that runs sublaterally	SAADL	lineage name: ABalppapapa	WBbt:0005007
Ring interneuron, anteriorly projecting process that runs sublaterally	SAADR	lineage name: ABarapppapa	WBbt:0005005
Ring interneuron, anteriorly projecting process that runs sublaterally	SAAVL	lineage name: ABplpaaaaaa	WBbt:0005003
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally	SMBVL	lineage name: ABalpapappp	WBbt:0004974
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally	SMBVR	lineage name: ABarappappp	WBbt:0004973
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally	SMBDL	lineage name: ABalpapapapp	WBbt:0004976
Ring motor neuron/interneuron, has a posteriorly direct ed process that runs sublaterally	SMBDR	lineage name: ABarappapapp	WBbt:0004975
Ring and ventral cord interneuron.	AVKL	lineage name: ABplpapapap	WBbt:0003845
Ring and ventral cord interneuron.	AVKR	lineage name: ABprpapapap	WBbt:0003844
Ring motor neuron/interneuron, many synapses	RMDL	lineage name: ABalpppapad	WBbt:0005037
Ring motor neuron/interneuron, many synapses	RMDR	lineage name: ABpraaaapad	WBbt:0005033
Ventral cord interneuron, like AVD but outputs restricted to anterior cord.	AVEL	lineage name: ABalpppaaaa	WBbt:0003864
Ventral cord interneuron, like AVD but outputs restricted to anterior cord.	AVER	lineage name: ABpraaaaaaa	WBbt:0003863
Ventral cord interneuron, synapses onto VA, DA, AS motorneurons; formerly called delta.	AVDL	lineage name: ABalaaapalr	WBbt:0003866
Ventral cord interneuron, synapses onto VA, DA, AS motorneurons; formerly called delta.	AVDR	lineage name: ABalaaapprl	WBbt:0003865
Neuron, synapses like AVHL/R	AVJR	lineage name: ABalapppppa	WBbt:0003846

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006778	unc-42	F58E6.10	Caenorhabditis elegans

4 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.		fully-elongated embryo Ce	WBls:0000021
	The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over.		elongating embryo Ce	WBls:0000015
	The C. elegans life stage spanning 210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes.		late cleavage stage embryo Ce	WBls:0000014
	A developemental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until death.		postembryonic Ce	WBls:0000022