WormMine: ExpressionPattern Expr730

• Pattern: Expression also observed in lumbar ganglion and preanal ganglion. Expression is first observed in embryos of 60 cells (nuclear localized), at the comma stage (400 min after fertilization) expression is localized mainly to the anterior portion of the embryo. After hatching and through the larval stages into developed adults expression is observed in both dorsal and ventral nerve cords, the nerve ring and also the nerve bodies that innervate the vulva. Expression also observed outside the nervous system, beta-gal staining observed anterior of the anterior pharyngeal bulb, where there are no neuronal cell bodies found.
• Primary Identifier: Expr730
• Remark: Difference in expression between male and hermaphrodite is observed near the tail. Expression is observed in the lumbar ganglial cells where particular neurons develop to innervate the tail rays in males. In the hermaphrodite tail, expression is observed that strongly resembles the position of neuronal cell bodies in the pre-anal and lumbar ganglia. This information was extracted from published material (Archana Sharma-Oates, Andrew Mounsey and Ian A. Hope).

6 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring.	ventral nerve cord	ventral cord	WBbt:0005829
the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes.	nerve ring	circumpharyngeal nerve ring	WBbt:0006749
a bundle of nerve processes that runs along the dorsal mid-line of the animal.	dorsal nerve cord	dorsal cord	WBbt:0006750
The left and right lumbar ganglia lie behind the pre-anal ganglion in the tail, in lateral positions. Each contains 12 neuron cell bodies that send most of their neuronal processes into the ventral nerve cord via lumbar commissures and the pre-anal ganglion. There is no local neuropil in these ganglia in the hermaphrodite, instead they form most synapses in the pre-anal ganglion. Most lumbar neurons have sensory functions. In the adult male tail, these two ganglia gain many additional neurons and have some local neuropil. The lumbar neurons lie in close association with the lateral hypodermis, and most are posterior to the anus.	lumbar ganglion	lumbar lateral ganglia	WBbt:0005830
ganglion anterior to the anus.	preanal ganglion		WBbt:0005448
Gonochoristic organism that can produce male gametes.	male	male organism	WBbt:0007850

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006843	unc-119	M142.1	Caenorhabditis elegans

6 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch.		L3 larva Ce	WBls:0000035
	The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2 larva Ce	WBls:0000027
	The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch.		L4 larva Ce	WBls:0000038
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003