WormMine: ExpressionPattern Expr11209

• Pattern: GFP-OIG- 4 was detected in puncta distributed along the ventral and dorsal nerve cords and in the nerve ring where head muscles are innervated. These puncta were juxtaposed to cholinergic varicosities stained with antibodies against the vesicular ACh transporter UNC-17 and colocalized with L-AChR clusters.Together, these results indicate that OIG-4 is a protein secreted by muscle cells, which clusters post-synaptically at cholinergic NMJs. In Pmyo-3::gfp-oig-4 transgenic animals, GFP-OIG-4 was readily detected in coelomocytes, thus demonstrating that the OIG-4 protein is effectively secreted from body-wall muscle cells.
• Primary Identifier: Expr11209
• Subcellular Localization: OIG-4 partially localizes at synapses.

5 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring.	ventral nerve cord	ventral cord	WBbt:0005829
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion.	body wall musculature	body muscle	WBbt:0005813
the most extensive region of neuropil in the animal, consists of a large toroidal bundle of processes.	nerve ring	circumpharyngeal nerve ring	WBbt:0006749
a bundle of nerve processes that runs along the dorsal mid-line of the animal.	dorsal nerve cord	dorsal cord	WBbt:0006750
neuron that uses vesicular acetylcholine as a neurotransmitter.	cholinergic neuron	ACh neuron	WBbt:0006840

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00043050	oig-4	R07G3.9	Caenorhabditis elegans

0 Life Stages