WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Life Stage :

Definition  At 20 Centigrade: 10-11 days after L4-adult molt. 13-14 days after first cleavage. Primary Identifier  WBls:0000674
Public Name  10-days post-L4 adult hermaphrodite Ce
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0 Anatomy Terms

2 Contained In

Remark Definition Other Name Public Name Primary Identifier
  The stage after an hermaphrodite animal is fully-developed and reaches maturity. adult hermaphrodite Ce WBls:0000057
  A C. elegans life stage that occurs during the adult life stage C. elegans life stage occurring during adulthood WBls:0000816

24 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  Transcripts that showed significantly increased expression in 10-days post L4 adult hermaphrodite N2 grown at 20C, comparing to in 1-day post L4 adult hermaphrodite N2 animals grown at 20C. CuffDiff, fold change > 2. WBPaper00065096:Day10_vs_Day1_upregulated
  Transcripts that showed significantly decreased expression in 10-days post L4 adult hermaphrodite npr-8(ok1439) animals grown at 20C, comparing to in N2 animals. CuffDiff, fold change > 2. WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
  Transcripts that showed significantly increased expression in 10-days post L4 adult hermaphrodite npr-8(ok1439) animals grown at 25C, comparing to in N2 animals. CuffDiff, fold change > 2. WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
  Proteins differently expressed in old Day 10 atm-1 (gk186) worms compared to all other conditions. N.A. WBPaper00051555:atm-1(gk186)_regulated_protein
  Proteins that showed signicantly increased expression in day 13 animals comparing to in day 4 animals. Proteins that significantly changed across replicates were identified using the rank product algorithm. The false discovery rate corresponding to each rank product was calculated by 10,000 random permutations of the ranks for each of the three replicates. At a 10% false discovery rate, 53 proteins significantly changed in abundance with age. WBPaper00048980:aging_upregulated
  Proteins that showed significantly increased expression in day 10 adults comparing to in day 1 adults at 20C. fold change > 2 WBPaper00064952:Day10_vs_Day1_upregulated_20C
  Proteins that showed significantly increased expression in day 10 adults comparing to in day 1 adults at 25C. fold change > 2 WBPaper00064952:Day10_vs_Day1_upregulated_25C
  Proteins that showed significantly increased expression in day 10 adults comparing to in day 5 adults at 20C. fold change > 2 WBPaper00064952:Day10_vs_Day5_upregulated_20C
  Proteins that showed significantly increased expression in day 10 adults comparing to in L4 larva at 20C. fold change > 2 WBPaper00064952:Day10_vs_L4_upregulated_20C
  Proteins that showed significantly increased expression in day 10 adults comparing to in L4 larva at 25C. fold change > 2 WBPaper00064952:Day10_vs_L4_upregulated_25C
  Transcripts that showed significantly increased expression in 10-days post L4 adult hermaphrodite npr-8(ok1439) animals grown at 20C, comparing to in N2 animals. CuffDiff, fold change > 2. WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
  Genes that showed differential expression in Day 1, 10 and 20 adult stages. Those genes showing statistically significant differences (FDR adjusted P < 0.05) by DESeq and edgeR at least between two time points or by the baySeq test over the three time points were regarded as DEGs (n = 3,608). WBPaper00048923:Aging_regulated
  Transcripts that showed significantly decreased expression in 10-days post L4 adult hermaphrodite N2 grown at 20C, comparing to in 1-day post L4 adult hermaphrodite N2 animals grown at 20C. CuffDiff, fold change > 2. WBPaper00065096:Day10_vs_Day1_downregulated
  Proteins that showed significantly decreased expression in day 10 adults comparing to in day 5 adults at 25C. fold change > 2 WBPaper00064952:Day10_vs_Day5_downregulated_25C
  Proteins that showed significantly decreased expression in day 10 adults comparing to in day 5 adults at 20C. fold change > 2 WBPaper00064952:Day10_vs_Day5_downregulated_20C
  Proteins that showed showed significant changes of expression level during aging process, according to SILAC LC-MS proteomic analysis. ANOVA, FDR < 0.05. WBPaper00049905:Age_variant_expression
  Proteins that showed significantly decreased expression in day 10 adults comparing to in L4 larva at 25C. fold change > 2 WBPaper00064952:Day10_vs_L4_downregulated_25C
  Proteins that showed significantly decreased expression in day 10 adults comparing to in L4 larva at 20C. fold change > 2 WBPaper00064952:Day10_vs_L4_downregulated_20C
  Proteins that showed significantly increased expression in day 10 adults comparing to in day 5 adults at 25C. fold change > 2 WBPaper00064952:Day10_vs_Day5_upregulated_25C
  Proteins that showed significantly decreased expression in day 10 adults comparing to in day 1 adults at 20C. fold change > 2 WBPaper00064952:Day10_vs_Day1_downregulated_20C
  Transcripts that showed significantly decreased expression in 10-days post L4 adult hermaphrodite npr-8(ok1439) animals grown at 25C, comparing to in N2 animals. CuffDiff, fold change > 2. WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
  Genes that increased expression in response to 50uM mianserin on adult day 10, which are not a response to aging. This is a list of 138 genes. The quasi-likelihood F-test from the edgeR package was used to test these counts for statistically significant differential gene expression between water- and mianserin-treated samples, while controlling for expression differences between the 3 biological replicates. We performed multiple testing correction by using the Benjamini-Hochberg procedure to compute a false discovery rate (FDR) value for each gene, and we considered an FDR less than 10% to be significant. WBPaper00048926:miaserin_upregulated_adult-day10
  Proteins that showed significantly decreased expression in day 10 adults comparing to in day 1 adults at 25C. fold change > 2 WBPaper00064952:Day10_vs_Day1_downregulated_25C
  Proteins that showed signicantly decreased expression in day 13 animals comparing to in day 4 animals. Proteins that significantly changed across replicates were identified using the rank product algorithm. The false discovery rate corresponding to each rank product was calculated by 10,000 random permutations of the ranks for each of the three replicates. At a 10% false discovery rate, 53 proteins significantly changed in abundance with age. WBPaper00048980:aging_downregulated

1 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr12367 ulp-4 expression initiates in body wall muscles (BWMs) and hypodermal cells during embryonic development and is maintained throughout the worm's life. During the development from larval stages 1-3, ulp-4 is expressed in the pharynx and hypodermis. A second phase of ulp-4 expression in BWMs and hermaphroditic-specific neurons (HSNs) starts at L4 stage and continues through adulthood. In each tissue, ULP-4 protein initially localizes to the cell's nucleus and cytoplasm but accumulates later in development in intracellular compartments that resemble mitochondria. High-resolution optical cross-sections through the organelle suggest that ULP-4 accumulates in the mitochondrial matrix.

2 Followed By

Remark Definition Other Name Public Name Primary Identifier
  At 20 Centigrade: 11-15 days after L4-adult molt. 14-18 days after first cleavage. 11-15 days post-L4 adult hermaphrodite Ce WBls:0000074
  At 20 Centigrade: 11-12 days after L4-adult molt. 14-15 days after first cleavage. 11-days post-L4 adult hermaphrodite Ce WBls:0000797

1 Preceded By

Remark Definition Other Name Public Name Primary Identifier
  At 20 Centigrade: 9-10 days after L4-adult molt. 12-13 days after first cleavage. 9-days post-L4 adult hermaphrodite Ce WBls:0000673

0 Sub Stages