WormMine: ExpressionPattern Expr14951

• Pattern: In dauer animals, expression was observed in the intestine, five neurons, and faintly in the hypodermis. Intestinal expression starts from the posterior in uncommitted L2d and spreads throughout the entire intestine after dauer-commitment. Intestinal expression peaks in intensity during dauer, dims in starved and aged dauers, and disappears from the center of the intestine in post-dauer L4s. Neuronal expression is detectable in 58% of the dauer-committed L2d (n 1/4 15/26), and exists in all dauers (n 1/4 31). The neurons consist of one pair immediately anterior to the terminal bulb of the pharynx, with processes that end in the nerve ring, and one triplet approximately one cell body diameter posterior to the metacorpus, with processes that end in the nose. Based on their positions and morphologies, the best candidates for the neuron identities include: ADF, ADL, AFD, AIA, AIB, ASG, ASH, ASI, ASK, AWA, AWB, AWC, BAG, IL1, IL2, and OLQ. Using colocalization markers, we eliminated AIB, AWC, BAG, IL1, IL2, and OLQ as the ets-10-expressing neurons. The precise identities of the neurons remain unknown. In dauer animals, expression was observed in the intestine, five neurons, and faintly in the hypodermis. Intestinal expression starts from the posterior in uncommitted L2d and spreads throughout the entire intestine after dauer-commitment. Intestinal expression peaks in intensity during dauer, dims in starved and aged dauers, and disappears from the center of the intestine in post-dauer L4s. Neuronal expression is detectable in 58% of the dauer-committed L2d (n = 15/26), and exists in all dauers (n = 31). The neurons consist of one pair immediately anterior to the terminal bulb of the pharynx, with processes that end in the nerve ring, and one triplet approximately one cell body diameter posterior to the metacorpus, with processes that end in the nose. Based on their positions and morphologies, the best candidates for the neuron identities include: ADF, ADL, AFD, AIA, AIB, ASG, ASH, ASI, ASK, AWA, AWB, AWC, BAG, IL1, IL2, and OLQ. Using colocalization markers, we eliminated AIB, AWC, BAG, IL1, IL2, and OLQ as the ets-10-expressing neurons. The precise identities of the neurons remain unknown.
• Primary Identifier: Expr14951

3 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00016870	ets-10	C52B9.11	Caenorhabditis elegans

2 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	A third stage larva specialized for dispersal and long term survival.		dauer larva Ce	WBls:0000032
	A special second stage larva with altered physiology and developmental potential that leads to formation of dauer larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch.		L2d larva Ce	WBls:0000046