WormMine: AnatomyTerm WBbt:0005660

• Definition: Neuron class of two neurons that have dual ciliated endings in the amphid sensillum. The endings are in the amphid channel, which is open to the outside. Processes from lateral cell bodies enter the ventral cord via the amphidial commissures and turn anteriorly to enter the nerve ring. The processes of ADF run near the outside surface and posterior face of the ring, in close association with those of AIZ. They meet at the dorsal mid-line and terminate; there is a gap junction at the point or contact. The main synaptic output is to RIA and AIZ; there are also synapses to SMB, AUA and RIR, usually in dyadic combinations with RIA or AIZ. AWB synapses onto ADF in several places, and there are gap junctions to RIH, ADA and AIA.
• Name: ADF
• Primary Identifier: WBbt:0005660

2 Children

Definition	Name	Synonym	Primary Identifier
Amphid neuron, prob. chemosensory	ADFL	lineage name: ABalpppppaa	WBbt:0004003
Amphid neuron, prob. chemosensory	ADFR	lineage name: ABpraaappaa	WBbt:0003999

3 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Top 300 transcripts enriched in ADF, ADL, AFD, ASE, ASG, ASH, ASI, ASJ, ASK, AWA, AWB, AWC according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:Ciliated_amphid_neuron
	Single-cell RNA-Seq cell group 148 expressed in: ADF.	CellRanger, DecontX, Monocle3, Louvain algorithm.	WBPaper00065623:148
	Transcripts enriched in ADF according to single cell RNAseq.	Genes that pass the Bonferroni threshold for multiple comparisons (q < 0.05) are significantly enriched.	WBPaper00061651:ADF_enriched

0 Expression Patterns

0 Life Stages

3 Parents

Definition	Name	Synonym	Primary Identifier
neuron that uses serotonin as a vesicular neurotransmitter.	serotonergic neuron	5-HT neuron	WBbt:0006837
neuron of the amphid sensillum	amphid neuron	amphid sensory neuron	WBbt:0005394
neuron that senses soluable chemicals	chemosensory neuron		WBbt:0005837