WormMine: AnatomyTerm WBbt:0005662

• Definition: Neuron class of two ciliated neurons that are part of the amphid sensillum; the endings of AFD have numerous villi, which poke into the amphid sheath cells.
• Name: AFD
• Primary Identifier: WBbt:0005662

2 Children

Definition	Name	Synonym	Primary Identifier
Amphid finger cell, neuron associated with amphid sheath	AFDR	lineage name: ABpraaaapav	WBbt:0003991
Amphid finger cell, neuron associated with amphid sheath	AFDL	lineage name: ABalpppapav	WBbt:0003993

10 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
Temperature Shift: 25C vs 15C for 16 hours at L4 larva stage.	Transcripts that showed significantly decreased expression in AFD neurons comparing to in whole animals.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00065158:AFD_depleted
Temperature Shift: 25C vs 15C for 16 hours at L4 larva stage.	Transcripts that showed significantly increased expression in AFD neurons comparing to in whole animals.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00065158:AFD_enriched
Temperature Shift: 25C vs 15C for 16 hours at L4 larva stage.	Transcripts that showed significantly increased expression in AFD neurons at lin-15(n765ts); oyIs95 animals shifted from 20C to 25C for 16 hours at L4 larva stage, comparing to animals shifted from 20C to 15C for 16 hours at L4 larva stage.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00065158:25C_vs_15C_upregulated_AFD
	Transcripts that showed significantly altered expression at AFD neurons in camt-1(ok515) animals comparing to in wild type AX1888-1 strain.	RNA-seq data were mapped using PRAGUI - a Python 3-based pipeline for RNA-seq data analysis.	WBPaper00061902:camt-1(ok515)_regulated_AFD
Temperature Shift: 25C vs 15C for 16 hours at L4 larva stage.	Transcripts that showed significantly decreased expression in AFD neurons at lin-15(n765ts); oyIs95 animals shifted from 20C to 25C for 16 hours at L4 larva stage, comparing to animals shifted from 20C to 15C for 16 hours at L4 larva stage.	DESeq2, fold change > 2, FDR < 0.05.	WBPaper00065158:25C_vs_15C_downregulated_AFD
	Transcripts that showed significantly increased expression in AFD neuron cells comparing to in whole animal, according to dissected single neuron RNASeq analysis.	Fold change >= 4.	WBPaper00050344:AFD-neuron_enriched
	Top 300 transcripts enriched in ADF, ADL, AFD, ASE, ASG, ASH, ASI, ASJ, ASK, AWA, AWB, AWC according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:Ciliated_amphid_neuron
	Proteins enriched in AFD neurons according to TurboID-based enzymatic protein labeling and extraction of biotinylated proteins.	N.A.	WBPaper00061818:AFD_enriched_protein
	Single-cell RNA-Seq cell group 125 expressed in: AFD.	CellRanger, DecontX, Monocle3, Louvain algorithm.	WBPaper00065623:125
	Transcripts enriched in AFD according to single cell RNAseq.	Genes that pass the Bonferroni threshold for multiple comparisons (q < 0.05) are significantly enriched.	WBPaper00061651:AFD_enriched

0 Expression Patterns

0 Life Stages

3 Parents

Definition	Name	Synonym	Primary Identifier
neuron of the amphid sensillum	amphid neuron	amphid sensory neuron	WBbt:0005394
neuron that senses changes of CO2 concentration in the environment.	carbon dioxide sensory neuron	CO2 sensory neuron	WBbt:0008430
neuron that senses temperature	thermosensory neuron		WBbt:0005838