WormMine: Gene WBGene00021615

• WormBase Gene ID: WBGene00021615
• Gene Name: Y47C4A.1
• Sequence Name: Y47C4A.1
• Organism: Caenorhabditis elegans
• Automated Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Is an ortholog of human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).
• Biotype: SO:0001217
• Genetic Position: :±
• Length (nt): 6500

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00021615

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Y47C4A.1.1	Y47C4A.1.1	1167	X: 279717-286216

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y47C4A.1	Y47C4A.1	1167	X: 279717-279791

3 RNAi Result

• WBRNAi00055284
• WBRNAi00058292
• WBRNAi00075519

47 Allele

• gk963652
• gk962800
• WBVar02121672
• WBVar02123728
• gk964065
• gk964321
• WBVar02123605
• WBVar02121497
• WBVar02123548
• WBVar02122173
• WBVar02122719
• WBVar02121057
• WBVar02063462
• WBVar01600261
• WBVar00247293
• WBVar01978964
• gk337271
• gk684120
• gk846256
• gk774830
• gk426366
• gk363706
• gk591897
• gk532415
• gk884133
• gk848533
• gk594688
• gk798864
• gk845135
• gk536520

1 Chromosome

• WormBase ID: X
• Organism: Caenorhabditis elegans
• Length (nt): 17718942

1 Chromosome Location

• Feature . Primary Identifier: WBGene00021615
• Start: 279717
• End: 286216
• Strand: -1

4 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set
• C. elegans genomic annotations (GFF3 Gene)
• Panther orthologue and paralogue predictions

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrX_277845..279716
• Length (nt): 1872
• Chromosome Location: X: 277845-279716
• Organism: Caenorhabditis elegans

7 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in daf-16(mgDf50) comparing to in N2 at L1 larva stage.	DESeq v1.20.0 was used to analyze differential gene expression. Transcripts with adjusted p-value < 0.05 were considered differentialled expressed.	WBPaper00048971:daf-16(mgDf50)_downregulated_L1
	Genes that were not enriched in either spermatogenic fem-3(q96gf) nor oogenic fog-2(q71) gonads, according to RNAseq analysis.	To identify differentially expressed transcripts, authors used R/Bioconductor package DESeq.	WBPaper00045521:Gender_Neutral
	Transcripts that showed significantly decreased expression in emb-4(hc60) comparing to in N2.	DESeq2	WBPaper00052884:emb-4(hc60)_downregulated
	Genes identified by ChIP-Seq analysis that are detected in both klf-1 overexpressor worms and isp-1;ctb-1 mutants	N.A.	WBPaper00059194:KLF-1_interacting
	Genes that showed significantly decreased expression level in rsr-2(RNAi) animals comparing to in gfp(RNAi) control.	Fold change > 1.2 or < 0.8.	WBPaper00042477:rsr-2(RNAi)_downregulated_TilingArray
	Transcripts that showed significantly decreased expression in animals lacking P granules by RNAi experiments targeting pgl-1, pgl-3, glh-1 and glh-4, and unc-119-GFP(+), comparing to in control animals, at 2-day post L4 adult hermaphrodite stage.	DESeq2, Benjamini-Hochberg multiple hypothesis corrected p-value < 0.05 and fold change > 2.	WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
	Transcripts that showed significantly decreased expression in hlh-26(ok1453) animals exposed to E. faecium for 8 hours, comparing to N2 animals exposed to E. faecium for 8 hours.	Fold change > 2.	WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium

1 Expression Patterns

• Primary Identifier: Expr1160194
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015

10 GO Annotation

6 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00021615
• Start: 279717
• End: 286216
• Strand: -1

10 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 6500

1 Sequence Ontology Term