WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0006915 apoptotic process GO

Namespace  biological_process Obsolete  false
Description  A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

121 Ontology Annotations

Annotation Extension Qualifier
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occurs_in(WBbt:0005784),happens_during(GO:0050829) involved_in
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19 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0071840 cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0016043 cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0022607 cellular component assembly The aggregation, arrangement and bonding together of a cellular component.
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0097190 apoptotic signaling pathway The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
GO:0120036 plasma membrane bounded cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.
GO:0030030 cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
GO:0120031 plasma membrane bounded cell projection assembly Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.
GO:0006915 apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GO:0097194 execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
GO:0008219 cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
GO:0012501 programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GO:0030031 cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
GO:0032060 bleb assembly The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.

557 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0006915 GO:0001781
is_a GO:0006915 GO:0001783
part of GO:0006915 GO:0001836
is_a GO:0006915 GO:0002342
is_a GO:0006915 GO:0002454
is_a GO:0006915 GO:0002516
regulates GO:0006915 GO:0002867
negatively regulates GO:0006915 GO:0002868
regulates GO:0006915 GO:0002868
regulates GO:0006915 GO:0002869
positively regulates GO:0006915 GO:0002869
regulates GO:0006915 GO:0002898
regulates GO:0006915 GO:0002899
negatively regulates GO:0006915 GO:0002899
positively regulates GO:0006915 GO:0002900
regulates GO:0006915 GO:0002900
is_a GO:0006915 GO:0002901
regulates GO:0006915 GO:0002902
negatively regulates GO:0006915 GO:0002903
regulates GO:0006915 GO:0002903
positively regulates GO:0006915 GO:0002904
regulates GO:0006915 GO:0002904
regulates GO:0006915 GO:0002905
negatively regulates GO:0006915 GO:0002906
regulates GO:0006915 GO:0002906
positively regulates GO:0006915 GO:0002907
regulates GO:0006915 GO:0002907
regulates GO:0006915 GO:0002908
negatively regulates GO:0006915 GO:0002909
regulates GO:0006915 GO:0002909

18 Synonyms

Name Type
apoptosis synonym
apoptosis activator activity synonym
apoptotic program synonym
apoptotic programmed cell death synonym
apoptosis signaling synonym
apoptotic cell death synonym
cellular suicide synonym
commitment to apoptosis synonym
caspase-dependent programmed cell death synonym
cell suicide synonym
programmed cell death by apoptosis synonym
signaling (initiator) caspase activity synonym
induction of apoptosis synonym
induction of apoptosis by p53 synonym
GO:0008632 alt_id
activation of apoptosis synonym
type I programmed cell death synonym
GO:0006917 alt_id