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GO:0009987
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cellular process
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Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. |
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GO:0008150
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biological_process
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A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. |
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GO:0071840
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cellular component organization or biogenesis
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A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. |
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GO:0016043
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cellular component organization
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A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. |
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GO:0003674
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molecular_function
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A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. |
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GO:0003824
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catalytic activity
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Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
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GO:0044238
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primary metabolic process
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The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. |
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GO:0090304
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nucleic acid metabolic process
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Any cellular metabolic process involving nucleic acids. |
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GO:0006139
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nucleobase-containing compound metabolic process
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Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. |
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GO:0006259
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DNA metabolic process
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Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. |
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GO:0008152
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metabolic process
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A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation. |
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GO:0043170
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macromolecule metabolic process
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The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. |
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GO:0004536
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DNA nuclease activity
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Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. |
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GO:0004518
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nuclease activity
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Catalysis of the hydrolysis of ester linkages within nucleic acids. |
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GO:0140640
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catalytic activity, acting on a nucleic acid
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Catalytic activity that acts to modify a nucleic acid. |
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GO:0140097
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catalytic activity, acting on DNA
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Catalytic activity that acts to modify DNA. |
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GO:0016787
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hydrolase activity
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Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
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GO:0016788
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hydrolase activity, acting on ester bonds
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Catalysis of the hydrolysis of any ester bond. |
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GO:0009056
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catabolic process
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A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. |
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GO:0141188
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nucleic acid catabolic process
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The cellular DNA metabolic process resulting in the breakdown of a nucleic acid. |
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GO:0009057
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macromolecule catabolic process
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The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. |
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GO:0034655
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nucleobase-containing compound catabolic process
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The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. |
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GO:0022411
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cellular component disassembly
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A cellular process that results in the breakdown of a cellular component. |
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GO:0006915
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apoptotic process
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A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
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GO:0097194
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execution phase of apoptosis
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A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
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GO:0008219
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cell death
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Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). |
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GO:0012501
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programmed cell death
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A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. |
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GO:0006308
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DNA catabolic process
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The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. |
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GO:0030262
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apoptotic nuclear changes
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Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. |
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GO:0006309
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apoptotic DNA fragmentation
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The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. |
