WormMine: ExpressionPattern Expr9584

• Pattern: hlh-14 is first expressed at the AB64-cell stage. hlh-14 expression appears to persist longer in posterior parts of the ABalppp/praaa lineage than in anterior parts. In the ASE branch, located at the posterior part of the lineage, hlh-14 expression is maintained throughout the lineage until shortly before the terminal division of the ASE neurons. In addition to its expression in the ASE lineage, it was observed by 4Dlineage analysis that the hlh-14 fosmid reporter is expressed in several other neuronal lineages. In some instances this expression is bilaterally symmetric, such as in the neuroblasts that give rise to the L/R bilaterally symmetric PLM/ALN neuronal pairs, PVQ/HSN/ PHB neuron pairs and the ALM/BDU neuron pairs. Surprisingly, in other instances this expression is L/R asymmetric, such as in neuroblasts of the C lineage. We observe asymmetric expression in two asymmetrically generated neuroblasts, the Caapa neuroblast that gives rise to the DVC neuron and a cell death, and the Caappv cell, which differentiates into the neuron PVR. The bilateral homologs of these hlh-14-expressing neuroblasts are non-neuronal hypodermal cells. Intriguingly, we also observe expression in the bilaterally symmetric neuroblasts that produce a pair of pharyngeal interneurons known as I1L/I1R. Finally, we observe later expression of hlh-14 in currently unidentified lineages, at a time in which all terminally differentiated cells present at hatching are already formed.
• Primary Identifier: Expr9584

22 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Herm. specific motor neurons (die in male embryo), innervate vulval muscles, serotonergic	HSNL	lineage name: ABplapppappa	WBbt:0004758
Herm. specific motor neurons (die in male embryo), innervate vulval muscles, serotonergic	HSNR	lineage name: ABprapppappa	WBbt:0004757
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil	ASEL	lineage name: ABalppppppaa	WBbt:0003904
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil	ASER	lineage name: ABpraaapppaa	WBbt:0003903
Interneuron, projects along ventral cord to ring	PVQL	lineage name: ABplapppaaa	WBbt:0004076
Interneuron, projects along ventral cord to ring	PVQR	lineage name: ABprapppaaa	WBbt:0004074
Phasmid neurons, probably chemosensory	PHBL	lineage name: ABplapppappp	WBbt:0004364
Phasmid neuron, probably chemosensory	PHBR	lineage name: ABprapppappp	WBbt:0005659
Pharyngeal interneurons: ant sensory, input from RIP	I1L	lineage name: ABalpapppaa	WBbt:0004746
Pharyngeal interneurons: ant sensory, input from RIP	I1R	lineage name: ABarapappaa	WBbt:0004745
Neuron, process runs along excretory canal and into ring, unique darkly staining synaptic vesicles	BDUL	lineage name: ABarppaappp	WBbt:0003812
Neuron, process runs along excretory canal and into ring, unique darkly staining synaptic vesicles	BDUR	lineage name: ABarpppappp	WBbt:0003811
Anterior lateral microtubule cell, touch receptor	ALML	lineage name: ABarppaappa	WBbt:0003954
Anterior lateral microtubule cell, touch receptor	ALMR	lineage name: ABarpppappa	WBbt:0003953
Posterior lateral microtubule cell, touch receptor	PLML	lineage name: ABplapappppaa	WBbt:0004104
Posterior lateral microtubule cell, touch receptor	PLMR	lineage name: ABprapappppaa	WBbt:0004103
Neuron class of one asymmetric interneuron, projects along ventral cord to ring, sends process into tail spike.	PVR	lineage name: Caappv	WBbt:0004072
Neuron class of one ring interneuron, cell body in dorsorectal ganglion.	DVC	lineage name: Caapaa	WBbt:0004821
embryonic cell	ABalppp		WBbt:0006048
embryonic cell	ABpraaa		WBbt:0006228
post-embryonic cell of pedigree Caappv	Caappv		WBbt:0007105
embryonic cell	Caapa		WBbt:0006123

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001958	hlh-14	C18A3.8	Caenorhabditis elegans

0 Life Stages