WormMine: ExpressionPattern Expr8280

• Pattern: DDB-1::GFP expression was also observed in a subset of cells that do not proliferate during the larval stages, including the lateral hyp7 hypodermal cells, rectal gland and epithelial cells, and a subset of neuronal cells in the head and tail regions. Additionally, adult hermaphrodites exhibit high-level expression in the spermatheca. DDB-1::GFP expression from the transgenic array was not observed in germ cells, but this may be due to transgene silencing in the germ line. In embryos, authors did not observe significant zygotic DDB-1::GFP expression. In larvae, DDB-1::GFP expression was observed in blast cells that proliferate during the larval stages, including seam cells in the lateral hypodermis, P cells in the ventral hypodermis, and intestinal cells. The P-cell lineage has the longest quiescent period between rounds of cell division, and within the P lineage, DDB-1::GFP expression correlates with the proliferative state. P blast cells did not express DDB1::GFP in newly hatched L1 larvae; however, expression was observed later in the L1 stage as the cells began to proliferate. During the L2 stage, the P-cell descendants are either quiescent or postmitotic, and they lack DDB-1::GFP expression. DDB-1::GFP expression resumes during the L3 stage in the P-cell descendants that create the vulva (the vulval precursor cells [VPCs]), as they move from quiescence to proliferation, and expression continues through the L4 stage. In adults, all P cell descendants are postmitotic, and DDB-1::GFP is not expressed.
• Primary Identifier: Expr8280
• Remark: Picture: Figure 2.

42 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
an accordion-like tube that contains sperm and is the site of oocyte fertilization.	spermatheca		WBbt:0005319
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
neuron with its cell body situated in the tail, posterior to rectum.	tail neuron		WBbt:0006759
entire syncytium of hyp7	hyp7 syncytium	hyp7	WBbt:0005734
Posterior descendent cell of P2 fuses into postembryonic large hypodermal syncytium hyp7.	P2.p		WBbt:0006890
Posterior descendent cell of P1 fuses into postembryonic large hypodermal syncytium hyp7.	P1.p		WBbt:0006889
descendent cell of P12, posterior	P12.p		WBbt:0006900
descendent cell of P11, posterior	P11.p		WBbt:0006899
descendent cell of P10, posterior	P10.p		WBbt:0006898
Posterior descendent cell of P9 fuses into postembryonic large hypodermal syncytium hyp7.	P9.p		WBbt:0006897
	P6.p hermaphrodite		WBbt:0008125
descendent cell of post-embryonic blast cell P5, posterior, in hermaphrodite.	P5.p hermaphrodite		WBbt:0008121
descendent cell of post-embryonic blast cell P4, posterior, in hermaphrodite.	P4.p hermaphrodite		WBbt:0008117
descendent cell of post-embryonic blast cell P3, posterior in hermaphrodite.	P3.p hermaphrodite		WBbt:0008112
	P8.p hermaphrodite		WBbt:0008133
	P7.p hermaphrodite		WBbt:0008129
	rectal gland cell		WBbt:0005799
cell, posteior daughter of P6.p	P6.pp		WBbt:0006988
cell, anterior daughter of P6.p	P6.pa		WBbt:0006987
cell, posterior descendent of P7.p	P7.pp		WBbt:0006984
cell, anterior descendent of P7.p	P7.pa		WBbt:0006983
post-embryonic cell of pedigree P5.pa	P5.pa		WBbt:0007252
cell, anterior daughter of P6.pp	P6.ppa		WBbt:0006991
cell, posterior daughter of P6.pa	P6.pap		WBbt:0006990
cell, anterior daughter of P6.pa	P6.paa		WBbt:0006989
post-embryonic cell of pedigree P5.ppa	P5.ppa		WBbt:0007256
post-embryonic cell of pedigree P5.pp	P5.pp		WBbt:0007255
post-embryonic cell of pedigree P5.pap	P5.pap		WBbt:0007254
post-embryonic cell of pedigree P5.paa	P5.paa		WBbt:0007253
post-embryonic cell of pedigree P7.ppp	P7.ppp		WBbt:0007266

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00010890	ddb-1	M18.5	Caenorhabditis elegans

0 Life Stages