WormMine: ExpressionPattern Expr2809

• Pattern: The gfp-tagged genomic exc-4 locus, which is capable of rescuing the exc-4 mutant phenotype, shows expression in the excretory system, hypodermis, vulva, pharyngeal muscle, rectal gland, tubular rectal epithelial cells, and tubular neuronal support cells in the head and tail. EXC-4 protein showed highly specific patterns of subcellular localization. Taken together, EXC-4 localizes to very distinct membranes that undergo substantial remodeling (growth and fusion) in order to create diverse, often tubular membrane structures. EXC-4 localizes in amphid sheath cells in the head and epithelial cells in the anus.
• Primary Identifier: Expr2809
• Subcellular Localization: In the excretory system, EXC-4 localizes to the lumenal membrane of the excretory cell, the duct, and the pore cell. Apical lumenal localization is also observed in the tubeforming cells generating the anus. In the lateral seam cells of the hypodermis, EXC-4 localizes directly adjacent to the adherens junction marker AJM-1 to a compact subapical belt of plasma membrane called the apical junction. In phasmid and labial sheath cells, EXC-4 selectively localizes to the extreme tip of the sheath cell membranes, which enwrap the dendritic ending of sensory neurons and fuse with themselves to form an elongated tubular structure exposed to the sensory environment.

7 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
female genital.	vulva		WBbt:0006748
type of cells that make up muscle layers in the pharynx.	pharyngeal muscle cell		WBbt:0005451
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
	excretory system		WBbt:0005736
	rectal gland cell		WBbt:0005799
epithelium connecting intestine and anus.	rectal epithelium		WBbt:0005800
sheath cell of amphid sensillum.	amphid sheath cell		WBbt:0006754

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00001365	exc-4	Y105E8A.22	Caenorhabditis elegans

0 Life Stages