WormMine: ExpressionPattern Expr1293

• Pattern: Strong expression of the LIN-25 protein is detected in all six VPCs. Expression begins in the L1 stage and remains strong up until the time the VPCs divide. Shortly after division, staining becomes restricted to the six descendants of P5.p, P6.p and P7.p. Thereafter LIN-25 expression is detected in all descendants of P5.p, P6.p and P7.p through both subsequent rounds of division. Staining is also detected in all descendants of P5.p, P6.p and P7.p during the early L4 stage, after morphogenesis has occurred. Elsewhere in the worm strong LIN-25 expression is seen in a number of cells, most notably the seam cells and many cells in the somatic gonad. Although many other cells are also stained weakly with the antiserum (such as the distal tip cells, the coelomocytes and the excretory cell), many cells fail to stain. Staining was not detected for example in nuclei in the hyp7 syncytium or in the hyp7 cytoplasm.
• Primary Identifier: Expr1293
• Subcellular Localization: Throughout all stages LIN-25 protein is detected in the nuclei of positive cells but appreciable cytoplasmic staining is also observed.

35 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Anterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad	anterior distal tip cell	gon herm dtc A	WBbt:0004520
Posterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad	posterior distal tip cell	gon herm dtc P	WBbt:0004506
H-shaped cell associated with the excretory system, largest cell in C. elegans.	excretory cell	excretory canal cell	WBbt:0005812
a group of hypodermal cells that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail	seam cell	lateral hypodermis	WBbt:0005753
A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles.	coelomocyte		WBbt:0005751
	P6.p hermaphrodite		WBbt:0008125
descendent cell of post-embryonic blast cell P5, posterior, in hermaphrodite.	P5.p hermaphrodite		WBbt:0008121
descendent cell of post-embryonic blast cell P4, posterior, in hermaphrodite.	P4.p hermaphrodite		WBbt:0008117
descendent cell of post-embryonic blast cell P3, posterior in hermaphrodite.	P3.p hermaphrodite		WBbt:0008112
	P8.p hermaphrodite		WBbt:0008133
	P7.p hermaphrodite		WBbt:0008129
adult vulval toroid cell, F, formed by fusion of precursors of lineage names P6.papl, P6.papr, P6.ppal and P6.ppar.	vulF		WBbt:0006768
adult vulval toroid cell, E, formed by fusion of precursors of lineage names P6.paal, P6.paar, P6.pppl and P6.pppr.	vulE		WBbt:0006767
organ producing either sperm or ova.	gonad		WBbt:0005175
cell, posteior daughter of P6.p	P6.pp		WBbt:0006988
cell, anterior daughter of P6.p	P6.pa		WBbt:0006987
cell, posterior descendent of P7.p	P7.pp		WBbt:0006984
cell, anterior descendent of P7.p	P7.pa		WBbt:0006983
post-embryonic cell of pedigree P5.pa	P5.pa		WBbt:0007252
cell, anterior daughter of P6.pp	P6.ppa		WBbt:0006991
cell, posterior daughter of P6.pa	P6.pap		WBbt:0006990
cell, anterior daughter of P6.pa	P6.paa		WBbt:0006989
post-embryonic cell of pedigree P5.ppa	P5.ppa		WBbt:0007256
post-embryonic cell of pedigree P5.pp	P5.pp		WBbt:0007255
post-embryonic cell of pedigree P5.pap	P5.pap		WBbt:0007254
post-embryonic cell of pedigree P5.paa	P5.paa		WBbt:0007253
post-embryonic cell of pedigree P7.ppp	P7.ppp		WBbt:0007266
post-embryonic cell of pedigree P7.ppa	P7.ppa		WBbt:0007265
post-embryonic cell of pedigree P7.pap	P7.pap		WBbt:0007264
post-embryonic cell of pedigree P6.ppp	P6.ppp		WBbt:0007260

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003011	lin-25	F56H9.5	Caenorhabditis elegans

1 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	A developmental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until adulthood.		larva Ce	WBls:0000023