WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  GFP-dependent fluorescence is observed organized into thin, circumferentially oriented stripes in regions of the hypodermis adjacent to muscle. This distribution is similar to that of hemidesmosome-associated cIFs. Furthermore, confocal microscopy shows that MUA-6/IFA-2::GFP codistributes with myotactin, a protein that colocalizes with hemidesmosome-associated intermediate filaments in the hypodermis of wild-type animals. MUA-6/IFA-2::GFP is also found in thin longitudinal stripes where the mechanosensory neurons interface with the hypodermis, a region of the hypodermis also shown to contain hemidesmosomes. Finally, MUA-6/IFA-2::GFP localizes to the uterine seam and prominent fibers are visualized within the uterinevulval cells. The MUA-6/IFA-2::GFP fusion protein can already be detected in embryos that are just starting to elongate. This stage is before hemidesmosome-associated intermediate filaments are recruited to regions of the hypodermis adjacent to muscle. By the three-fold stage of embryogenesis, the MUA-6/IFA-2::GFP fusion protein is detected in a pattern that is consistent with its becoming associated with hemidesmosomes. Primary Identifier  Expr2768
Subcellular Localization  Associated with hemidesmosomes.

5 Anatomy Terms

Definition Name Synonym Primary Identifier
Epidermal layer. hypodermis epidermis WBbt:0005733
uterine-vulval cell proximal to the vulva. uv1   WBbt:0006791
membranous cell attaches the uterus to the lateral epidermis (seam) and forms a thin laminar process dorsal to the vulva. formed by fusion of eight pi cell progeny and AC. uterine seam cell utse WBbt:0006789
uterine-vulva cell, distal (of three ut cells) to the vulva. uv3   WBbt:0006793
uterine-vulval cell, medial position of three ut cells. uv2   WBbt:0006792

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003485 mua-6 W10G6.3 Caenorhabditis elegans

7 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch. L2 larva Ce WBls:0000027
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038
  The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch. L1 larva Ce WBls:0000024
  The stage that begins when a C.elegans individual is fully-developed and has reached maturity. adult Ce WBls:0000041
  The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch. L3 larva Ce WBls:0000035
  The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo. fully-elongated embryo Ce WBls:0000021
  The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over. elongating embryo Ce WBls:0000015