WormMine: Gene WBGene00189937

• WormBase Gene ID: WBGene00189937
• Gene Name: Y6G8.15
• Sequence Name: Y6G8.15
• Organism: Caenorhabditis elegans
• Automated Description: Is affected by several genes including csr-1; rrf-3; and tph-1 based on RNA-seq studies. Is affected by seven chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq studies. Is predicted to encode a protein with the following domains: PAN domain and PAN/Apple domain.
• Biotype: SO:0001217
• Genetic Position: :±
• Length (nt): 619

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Synonyms

• Value: WBGene00189937

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Y6G8.15.1	Y6G8.15.1	514	V: 17609985-17610603

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y6G8.15	Y6G8.15	456	V: 17610036-17610161

0 RNAi Result

26 Allele

• gk963271
• gk963489
• gk963304
• gk963637
• WBVar02123303
• gk964050
• WBVar02124059
• gk962704
• gk962630
• WBVar02122699
• WBVar02121656
• WBVar02124636
• WBVar02123716
• WBVar02122260
• gk964150
• WBVar02123937
• WBVar02124501
• WBVar02124503
• WBVar02122261
• WBVar01464769
• WBVar01464770
• WBVar02055126
• gk870566
• gk807761
• WBVar01812250
• WBVar01812249

1 Chromosome

• WormBase ID: V
• Organism: Caenorhabditis elegans
• Length (nt): 20924180

1 Chromosome Location

• Feature . Primary Identifier: WBGene00189937
• Start: 17609985
• End: 17610603
• Strand: -1

2 Data Sets

• WormBaseAcedbConverter
• C. elegans genomic annotations (GFF3 Gene)

1 Downstream Intergenic Region

• WormBase ID: intergenic_region_chrV_17609598..17609984
• Length (nt): 387
• Chromosome Location: V: 17609598-17609984
• Organism: Caenorhabditis elegans

32 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly increased expression after animals were treated with 50uM Rifampicin and 250uM Allantoin from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rifampicin-Allantoin_upregulated
	Transcripts that showed significantly increased expression after animals were treated with 100uM Psora and 250uM Allantoin from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Psora-Allantoin_upregulated
	Transcripts that showed significantly increased expression after animals were treated with 100uM Rapamycin and 50mM Metformin from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rapamycin-Metformin_upregulated
	Transcripts that showed significantly decreased expression in miR-80(nDf53) comparing to in N2.	EdgeR fold change > 2, FDR < 0.05.	WBPaper00067295:miR-80(nDf53)_downregulated
	Transcripts that showed significantly decreased expression in dissected female germline comparing to in dissected male germline.	Log2 Fold change > 2 or <-1, p-value < 0.05.	WBPaper00053599:female_vs_male_downregulated
	Transcripts that showed significantly decreased expression in eat-2(ad1116) comparing to in N2 at 3-days post L4 adult hermaphrodite animals.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:eat-2(ad1116)_downregulated
Bacteria: B.thuringiensis	Transcripts in elt-2(RNAi) animals that were significantly differentially expressed at least for one time point on the non pathogenic strain Bt407 compared to E. coli OP50.	Cuffdiff	WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
Bacteria: B.thuringiensis	Transcripts in elt-2(RNAi) animals that were significantly differentially expressed at least for one time point and one pathogenic strain Bt247 and Bt679 compared to the non pathogenic strain Bt407.	Cuffdiff	WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
Bacteria: B.thuringiensis	Transcripts in N2 animals that were significantly differentially expressed at least for one time point and one pathogenic strain Bt247 and Bt679 compared to the non pathogenic strain Bt407.	Cuffdiff	WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
	Proteins identified in extracellular vesicle.	N.A.	WBPaper00062669:extracellular-vesicle_protein
Bacteria infection: Bacillus thuringiensis	Transcripts that showed significantly decreased expression in N2 animals infected by bacteria BMB171/Cry5Ba, an acrystalliferous Bt mutant BMB171 transformed with toxin gene cry5Ba on the shuttle vector pHT304, comparing to N2 animals infected by BMB171/pHT304.	N.A.	WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
	Transcripts that showed significantly decreased expression in csr-1a(tor159) comparing to in N2 at 25C.	DESeq2, fold change > 2, p-value < 0.05.	WBPaper00061753:csr-1(tor159)_downregulated_25C
	Transcripts that showed significantly decreased expression in emb-4(hc60) comparing to in N2.	DESeq2	WBPaper00052884:emb-4(hc60)_downregulated
	Transcripts that showed significantly increased expression in nhl-2(ok818) comparing to in N2 at 25C.	EdgeR, FDR < 0.05, fold change < 0.5.	WBPaper00055971:nhl-2(ok818)_25C_downregulated
	Transcripts that showed significantly increased expression after animals were treated with 100uM Rapamycin and 250uM Allantoin from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rapamycin-Allantoin_upregulated
	Transcripts that showed significantly increased expression after animals were treated with 100uM Rapamycin and 100uM Psora from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rapamycin-Psora_upregulated
	Transcripts that showed significantly increased expression after animals were treated with 100uM Rapamycin, 100uM Psora and 250uM Allantoin from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
	Transcripts that showed significantly increased expression after animals were treated with 100uM Rapamycin, 50uM Rifampicin and 100uM Psora from day 1 to day 3 adult hermaphradite.	DESeq2(v1.14.1), fold change > 2, p-value < 0.05	WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
	Transcripts that showed significantly decreased expression in csr-1a(tor159) comparing to in N2 at 20C.	DESeq2, fold change > 2, p-value < 0.05.	WBPaper00061753:csr-1(tor159)_downregulated_20C
	Transcripts that showed significantly decreased expression in cat-2(e1112);odIs77 comparing to in odIs77 control animals.	EdgeR, FDR<0.01	WBPaper00060921:cat-2(e1112)_downregulated
	Transcripts that showed significantly increased expression in nhr-42(tm1375) animals infected with S. aureus SH1000 for 5 h, comparing to in N2 animals infected with S. aureus SH1000 for 5 h.	Adjusted p-value (Padj) <= 0.01 was considered significant for differential gene expression.	WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
	Transcripts that showed significantly increased expression in uninfected nhr-42(tm1375) animals comparing to in uninfected N2 animals.	Adjusted p-value (Padj) <= 0.01 was considered significant for differential gene expression.	WBPaper00065225:nhr-42(tm1375)_upregulated_uninfected
	Transcripts that showed significantly decreased expression in N2 animals exposed to 30 uM CdCl2 for five days starting from L4.	edgeR, fold change > 2, p < 0.05.	WBPaper00066204:CdCl2_downregulated_mRNA
	Transcripts that showed significantly increased expression in adr-1(tm668) comparing to in N2.	DESeq2, p-value < 0.05 and a fold enrichment log2fold > 0.5.	WBPaper00055226:adr-1(tm668)_upregulated
	Transcripts that showed significantly increased expression in rrf-3(pk1426) comparing to in N2 at L4 larva stage.	DESeq2v 1.18.1, fold change > 1.5, adjusted p-value < 0.01.	WBPaper00056169:rrf-3(pk1426)_upregulated_L4
	Transcripts that showed significantly decreased expression in tbh-1(ok1196);odIs77 comparing to in odIs77 control animals.	EdgeR, FDR<0.01	WBPaper00060921:tbh-1(ok1196)_downregulated
	Transcripts that showed significantly decreased expression in nhr-8(hd117) comparing to in N2.	Differentially expressed genes were identified using Sleuth (version 0.30.0).	WBPaper00062446:nhr-8(hd117)_downregulated
	Transcripts that showed significantly decreased expression in rotr-1(ums53) comparing to in N2 animals.	Differentially expressed genes were identified using Sleuth (version 0.30.0).	WBPaper00067263:rotr-1(ums53)_downregulated
	Transcripts that showed significantly decreased expression in tph-1(mg280);odIs77 comparing to in odIs77 control animals.	EdgeR, FDR<0.01	WBPaper00060921:tph-1(mg280)_downregulated
	Transcripts that showed significantly decreased expression after exposed to 10ug per ml SiO2 nanoparticles from L1 larva to 1-day post L4 adult hermaphrodite stage.	edgeR, fold change > 2 (set by curator), FDR < 0.05.	WBPaper00059426:SiO2-nanoparticles_downregulated

3 Expression Patterns

• Primary Identifier: Expr1022237
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012

• Primary Identifier: Expr2008254
• Pattern: Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).

• Primary Identifier: Expr1161523
• Pattern: Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015

0 GO Annotation

0 Homologues

1 Locations

• Feature . Primary Identifier: WBGene00189937
• Start: 17609985
• End: 17610603
• Strand: -1

0 Ontology Annotations

0 Regulates Expr Cluster

1 Sequence

• Length: 619

1 Sequence Ontology Term