WormMine: ExpressionPattern Expr9916

• Pattern: RAB-6.2::GFP is highly expressed in body wall muscles, pharyngeal and vulval muscles, hypodermis, intestine, the gonad, coelomocytes, seam cells, vulval epithelia, distal tip cells, ventral cord dendrites, and neurons. We also introduced this transgene into nematodes that also express a Pglr-1::monomeric RFP (mRFP) transgene (Shim et al., 2004), and we found that RAB-6.2::GFP is expressed in the GLR-1-expressing command interneurons.
• Primary Identifier: Expr9916
• Subcellular Localization: RAB-6.2 is localized to punctate structures in the neuron cell body and along the ventral cord dendrites. We introduced the Pglr-1::cerulean:: rab-6.2 transgene into nematodes that express the Golgi resident protein mannosidase (MANS)::YFP (Rolls et al., 2002; Glodowski et al., 2005) and observed nearly complete colocalization between Cerulean::RAB-6.2 and MANS::YFP, indicating that RAB-6.2 is localized on or near Golgi structures.

13 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
female genital.	vulva		WBbt:0006748
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
somatic cell that situates at the tip of a gonad arm.	distal tip cell	DTC	WBbt:0006865
a large process bundle that runs along the vental mid-line extending from the ventral region of the nerve ring.	ventral nerve cord	ventral cord	WBbt:0005829
type of cells that make up muscle layers in the pharynx.	pharyngeal muscle cell		WBbt:0005451
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion.	body wall musculature	body muscle	WBbt:0005813
Epidermal layer.	hypodermis	epidermis	WBbt:0005733
muscle associated with hermaphrodite vulva.	vulval muscle		WBbt:0005821
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679
a group of hypodermal cells that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail	seam cell	lateral hypodermis	WBbt:0005753
A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles.	coelomocyte		WBbt:0005751
organ producing either sperm or ova.	gonad		WBbt:0005175
a type of interneurons whose synaptic output represent a final common pathway to motor neurons. The synaptic activities of command interneurons lead directly to the control of locomotion.	command interneuron	command neuron	WBbt:0007804

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004270	rab-6.2	T25G12.4	Caenorhabditis elegans

0 Life Stages