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WS294

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Expression Pattern :

Pattern  In summary, PEB-1 accumulated in L1 larvae in the nuclei of all hypodermal cells and the epithelial cells lining the rectal lumen. As in the pharynx, PEB-1 was not detectable in neuroblasts or differentiated neurons. PEB-1-expressing cells are not obviously related by cell type or lineage. Rather, one striking common feature of these cells is that they contact the cuticle on the exterior of the worm or lining the pharyngeal or rectal lumen. Like in the pharynx, PEB-1 was first detected in the hypodermal nuclei in comma stage embryos (approximately 400 min) and remained detectable until hatching. In 1 1/2-fold stage embryos, the PEB-1 protein was detected in the nuclei of most, if not all, hypodermal cells including hyp5, hyp6, and hyp7 and the H, P, and V cells. After hatching, PEB-1 remained detectable in most hypodermal cells although it decreased in later larvae and was undetectable in adults. In the L1 lateral hypodermis, the PEB-1 protein was detected in H0, H1, H2, V1 to V6, and T, and their anterior and posterior daughters, as well as in the nuclei of the hyp7 syncytium. PEB-1 was also detected in many of the dorsal and ventral hypodermal nuclei in the head and the ventral hypodermal nuclei in the tail. Notably, PEB-1 was not detected in larval P cells. In addition, PEB-1 was not detected in other neuroblasts including Q and T.p. PEB-1 was also expressed in cells lining the lumen of the hindgut. In 1 1/2-fold embryos (approximately 420 min), PEB-1 was detected in many nuclei near the posterior of the embryo. These likely include both the posterior hypodermal cells and hindgut cells, although these cells cannot be easily distinguished at this stage. In L1 larvae, PEB-1 was detected in many of the non-neuronal nuclei surrounding the rectal lumen, including K, K', U, F, B, and Y. PEB-1 was not detected in the rectal-intestinal valve or the anal depressor muscle. As in other tissues, the PEB-1 protein remained detectable in the hindgut throughout larval development but became progressively less abundant and undetectable in adults. Importantly, this progressive decrease in PEB-1 expression also occurs in Y, which withdraws from the hypodermis during late larval development to become a neuron. Primary Identifier  Expr3462
Remark  Interestingly, Y is replaced in the hindgut by P12.pa, a descendant of the only P cell in which PEB-1 protein expression was detected in L1 larvae. No detailed description on cellular expression patterns in pharynx, try to find those information in Expr838. Subcellular Localization  nuclei
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28 Anatomy Terms

Definition Name Synonym Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages. intestine gut WBbt:0005772
Epidermal layer. hypodermis epidermis WBbt:0005733
Seam hypodermal cell, postembryonic blast cell H1L lineage name: ABplaaappp WBbt:0004766
Seam hypodermal cell, postembryonic blast cell H1R lineage name: ABarpapppp WBbt:0004765
Seam hyopdermal cell, postemb. blast cell, L1 deirid socket H2L lineage name: ABarppaaap WBbt:0004764
Seam hyopdermal cell, postemb. blast cell, L1 deirid socket H2R lineage name: ABarpppaap WBbt:0004763
Seam hypodermal cell H0L lineage name: ABplaaappa WBbt:0004778
Seam hypodermal cell H0R lineage name: ABarpapppa WBbt:0004777
Tail seam hypodermal cell, postembryonic blast cell, functions as phasmid socket in L1 TL lineage name: ABplappppp WBbt:0004946
Tail seam hypodermal cell, postembryonic blast cell, functions as phasmid socket in L1 TR lineage name: ABprappppp WBbt:0004944
Rectal cell, postembryonic blast cell in male B cell lineage name: ABprppppapa WBbt:0003825
Rectal cell, blast cell in male F cell lineage name: ABplppppapp WBbt:0004799
Seam hypodermal cell, postembryonic blast cell V4L lineage name: ABarppappa WBbt:0004894
Seam hypodermal cell, postembryonic blast cell V4R lineage name: ABarpppppa WBbt:0004892
Seam hypodermal cell, postembryonic blast cell V5L lineage name: ABplapapaap WBbt:0004890
Seam hypodermal cell, postembryonic blast cell V5R lineage name: ABprapapaap WBbt:0004876
Seam hypodermal cell, postembryonic blast cell V2L lineage name: ABarppapap WBbt:0004902
Seam hypodermal cell, postembryonic blast cell V2R lineage name: ABarppppap WBbt:0004900
Seam hypodermal cell, postembryonic blast cell V3L lineage name: ABplappapa WBbt:0004898
Seam hypodermal cell, postembryonic blast cell V3R lineage name: ABprappapa WBbt:0004896
Seam hypodermal cell, postembryonic blast cell V1R lineage name: ABarppppaa WBbt:0004904
Seam hypodermal cell, postembryonic blast cell V1L lineage name: ABarppapaa WBbt:0004905
Seam hypodermal cell, postembryonic blast cell V6L lineage name: ABarppappp WBbt:0004875
Seam hypodermal cell, postembryonic blast cell V6R lineage name: ABarpppppp WBbt:0004874
Rectal cell, postembryonic blast cell in male U cell lineage name: ABplppppapa WBbt:0004942
Rectal cell, postembryonic blast cell K cell lineage name: ABplpapppaa WBbt:0004499
Rectal cell K' cell lineage name: ABplpapppap WBbt:0004497
Rectal cell at hatching, becomes PDA in hermaphrodite, postembryonic blast cell in male Y cell lineage name: ABprpppaaaa WBbt:0004578

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003968 peb-1 T14F9.4 Caenorhabditis elegans

10 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The second stage larva. At 25 Centigrade, it ranges 25.5-32.5 hours after fertilization, 11.5-18.5 hours after hatch. L2 larva Ce WBls:0000027
  The fourth stage larva. At 25 Centigrade, it ranges 40-49.5 hours after fertilization, 26-35.5 hours after hatch. L4 larva Ce WBls:0000038
  The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch. L1 larva Ce WBls:0000024
  The stage that begins when a C.elegans individual is fully-developed and has reached maturity. adult Ce WBls:0000041
  The third stage larva. At 25 Centigrade, it ranges 32.5-40 hours after fertilization, 18.5-26 hours after hatch. L3 larva Ce WBls:0000035
  The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo. fully-elongated embryo Ce WBls:0000021
  The C. elegans life stage spanning 520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage. 3-fold embryo Ce WBls:0000020
  The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo. 1.5-fold embryo Ce WBls:0000018
  The C. elegans life stage spanning 390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo. comma embryo Ce WBls:0000017
  The C. elegans life stage spanning 460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo. 2-fold embryo Ce WBls:0000019