| Algorithm | Genes were counted as significantly up or down regulated for L3 sleep-like if the calculated false discovery rate (FDR) was equal or smaller then 5.0% and the fold change was > 2. p-values were obtained from the moderated t-statistic and corrected with the Benjamini-Hochberg method.Only genes consistently up or down regulated in both the L3 and L4 molt were selected to eliminate the effect of developmental progression. Authors reasoned that gene expression changes that would be biologically relevant would oscillate with substantial amplitude in phase with the molting cycle. They applied an arbitrary threshold and selected only those genes that oscillated with an amplitude of at least 50%. | Description | Genes that were downregulated during lethargus (sleep-like) stage with oscillating expression, according to microarray analysis comparing L3 lethargus to L4 large, and L4 lethargus to young adult. |
| Primary Identifier | WBPaper00046024:sleep_downregulated_oscillating |
| Remark | Definition | Other Name | Public Name | Primary Identifier |
|---|---|---|---|---|
| The stage during L4-adult molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. | L4-adult lethargus Ce | WBls:0000039 | ||
| The stage during L3-L4 molt when an animal becomes lethargic, ceases pharyngeal pumping and synthesizes new cuticle under the old. | L3-L4 lethargus Ce | WBls:0000036 |
