WormMine: AnatomyTerm WBbt:0004517

• Definition: Inner labial socket
• Name: ILsoR
• Primary Identifier: WBbt:0004517
• Synonym: lineage name: ABalaaapprr

1 Children

Definition	Name	Synonym	Primary Identifier
nucleus of pedigree ABalaaapprr	ABalaaapprr nucleus		WBbt:0002126

1 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Top 300 transcripts enriched in ILsoL, ILsoR, ILsoDL, ILsoDR, ILsoVL, ILsoVR according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:ILso

24 Expression Patterns

• Primary Identifier: Expr4434
• Pattern: Expressed in socket cells of IL or OLQ. Strongly expressed in OLLL and OLLR neurons.

• Primary Identifier: Expr4439
• Pattern: Expressed in the seam cells at embryo. Expressed in socket cells of IL or OLQ. Expression shown in the intestine, usually stronger in the cells at the terminal regions.

• Primary Identifier: Expr4464
• Pattern: Expressed in the rectal epithelial cells from L1 and maintained through adulthood. Expressed in socket cells of IL or OLQ.

• Primary Identifier: Expr4456
• Pattern: Expressed in the hypodermis from embryo stage through adulthood. Expressed in the rectal epithelial cells from L1 and maintain through adulthood. Expressed in the terminal bulb of the pharynx. Expressed in socket cells of IL or OLQ.

• Primary Identifier: Expr4457
• Pattern: Expressed in socket cells of IL or OLQ.

• Primary Identifier: Expr4453
• Pattern: Expressed in socket cells of IL or OLQ.

• Primary Identifier: Expr4445
• Pattern: Expressed in socket cells of IL or OLQ. Expressed in the PVT cell.

• Primary Identifier: Expr4448
• Pattern: Expressed in the rectal epithelial cells from L1 and maintained through adulthood. Expressed in socket cells of IL or OLQ.

• Primary Identifier: Expr4440
• Pattern: Expressed in socket cells of IL or OLQ. Expressed in neurons of the lumbar ganglion, but the specific neurons were not identified.

• Primary Identifier: Expr4441
• Pattern: Expressed in socket cells of amphids, IL or OLQ.

• Primary Identifier: Marker30
• Remark: Picture: Fig. 1G, 1H, Fig S1G-L.
• Pattern: Expressed in CEPsh glia and in sheath and socket glia of inner and outer labial sensilla, and of the deirid.

• Primary Identifier: Expr11754
• Remark: Isoform 1a

• Primary Identifier: Expr11756
• Remark: Isoform 1b.2

• Primary Identifier: Expr8673
• Remark: Picture: Fig 3.
• Pattern: Expression in the alimentary canal: Strong and consistent expression in anterior arcades, posterior arcades, M1, B cell. Weak or rare expression in intestine. Expression in the nervous system: Amsh, CEPsh, CEPso, ILso, OLso, Phso, DVC, MI. Expression in the reproductive system: In adult stage, expressed in gonad sheath, uterus, vulva(low), spermatheca, Sp-ut valve. In developing larva stage, expressed in uterus, vulva, spermatheca, Sp-ut valve. inx-5 first appears in the developing hypodermis at bean stage and then in the excretory cell at three-fold stage.

• Primary Identifier: Expr8676
• Remark: Picture: Fig 3.
• Pattern: Expression in the alimentary canal: Strong and consistent expression in pm1, pm3. Weak or rare expression in pharyngeal epithelium, pm2, pm4, pm5, pm6, pm7, pm8, intestine, rectal epithelial cells. Expression in the nervous system: ILso, AIN, AVF, AVJ, AVK, PVR, SAB. Expression in the reproductive system: In adult stage, expressed in Gonad sheath, Vulva(low), vulval muscle, uterine muscle. In developing larva stage, expressed in vulval muscle, uterine muscle. inx-8 is expressed broadly, albeit at very low levels, around two-fold stage, and its expression becomes stronger in the pharynx, nervous tissue, HMC, and GLR cells as development continues. In the reproductive system, expression of inx-8 starts during early larval stages and continues during migrations of the great granddaughters of the SM blast cell to their final locations and after the sex muscles achieve their final structures. inx-8 is expressed in the hypodermal cells of the animal in postembryonic stages.

• Primary Identifier: Expr8906
• Remark: Picture: N.A.
• Pattern: Expressed in pm3 to pm5 in pharynx, all cells in intestine, hyp1, seam (weak), PDE neuron and ILso (uncertain).

• Primary Identifier: Expr15833

• Primary Identifier: Expr8680
• Remark: Picture: N.A.
• Pattern: Expression in the alimentary canal: Strong and consistent expression in M2, rectal epithelial cells. Weak or rare expression in anterior arcades, posterior arcades. Expression in the nervous system: Amsh, CEPso, ILso, OLso, PDEso, AVH (early larva), AVJ (early larva), AVK, CAN, IL1 (early larva), PDE, PVD, SIB (early larva), URB, VAn, VBn, M2. Expression in the reproductive system: In adult stage, expressed in vulva, spermatheca, sperm(spermatocytes, spermatids). In developing larva stage, expressed in vulva. inx-12 expressionstarts in seam precursors around 1.5-fold stage, followed by expression in arcade cells by 2-fold and head neurons by 3-fold stage. inx-12 is expressed in the hypodermal cells of the animal in postembryonic stages.

• Primary Identifier: Expr646
• Remark: Reporter gene fusion type not specified. This information was extracted from published material (Archana Sharma-Oates, Andrew Mounsey and Ian A. Hope).
• Pattern: wrt-6 is expressed in the nuclei of four to seven sheath and socket cells of the anterior sensilla. Staining is observed in amphid and inner labial socket cells. Some worms show additional staining in seam cells and hypodermal syncytia.

• Primary Identifier: Expr8930
• Remark: Picture: N.A.
• Pattern: Expressed in all intestinal cells(weak), major hypodermis, vulva epithelium, rectal epithelium, AMsh, IL/OLso and excretory duct cell.

• Primary Identifier: Expr8681
• Remark: Picture: N.A.
• Pattern: Arcade cells are seen to express inx-13 at high levels starting around two-fold stage continuing throughout development and adulthood. inx-13 is expressed in the hypodermal cells of the animal in postembryonic stages. Expression in the alimentary canal: Strong and consistent expression in M1, M2. Weak or rare expression in intestine, rectal epithelial cells. Expression in the nervous system: Amsh, CEPsh, CEPso, ILsh, ILso, OLsh, OLso, Phsh, CAN, DVA, DVB, DVC, LUA, PHA, PHB, PLN, PVC, PVQ, PVR, M1, M2. Expression in the reproductive system: In adult stage, expressed in spermatheca, sp-ut valve.

• Primary Identifier: Expr3225
• Remark: Reporter gene fusion type not specified.
• Pattern: LEV-8 is first detected in L1 animals in a single pair of neurons in the head, approximately midway along the isthmus. It is also expressed in the PVT interneuron situated in the lumbar ganglion, at the rear of the animal. By L4, LEV-8 is expressed in all six DD motor neurons in the ventral nerve cord. As well as expression in several neuronal cell types, LEV-8 is expressed in body wall and in uterine muscles UV1 and UV2. Expression in the body wall was strongest anteriorly, which accords with the higher level of resistance exhibited by the head muscles of lev-8(x15) mutant worms. In the adult worm, LEV-8 is expressed in many neurons in the anterior nervous system. One of the more prominent of these is a single cell in the dorsal ganglion, ALA. LEV-8 is expressed in the IL and OL socket cells but not the neurons themselves.

• Primary Identifier: Expr9160
• Remark: Picture: Fig. 3.
• Pattern: Expression of itx-1prom::gfp was observed in the intestinal tract of embryos from 1.5-fold stage throughout post-embryonic larval development and adulthood. Furthermore, GFP could be detected in socket cells ensheathing the inner and outer labial neurons. Expression could also be observed in the spermatheca and vulva muscle cells. No other cell type displays consistent reporter gene expression.

• Primary Identifier: Expr2425
• Remark: No detailed description on expression patterns in other life stages. Reporter gene fusion type not specified.
• Pattern: In adult hermaphrodites, F22A3.1 reporter expression was observed in the inner and outer labial socket cells of the head. F22A3.1 is expressed strongly in the seam cells within the hypodermal ridges, which extend bilaterally along the length of the exterior body wall. During the first larval stage, F22A3.1 also demonstrated expression in P-cells, the ventral hypodermal precursors, some of which form the vulva. In general, F22A3.1 seems to be quite specific to hypodermal tissues and is probably expressed in all hypodermal cells including glial-like cells.

12 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003
	The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.		fully-elongated embryo Ce	WBls:0000021
	The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over.		elongating embryo Ce	WBls:0000015
	The C. elegans life stage spanning 290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastrulation and is enclosing.		enclosing embryo Ce	WBls:0000013
	The C. elegans life stage spanning 100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation.		gastrulating embryo Ce	WBls:0000010
	The C. elegans life stage spanning 0-350min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 560 cells. From start of first cleavage until cleavage is over.		proliferating embryo Ce	WBls:0000004
	The C. elegans life stage spanning 520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage.		3-fold embryo Ce	WBls:0000020
	The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo.		1.5-fold embryo Ce	WBls:0000018
	The C. elegans life stage spanning 390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo.		comma embryo Ce	WBls:0000017
	The C. elegans life stage spanning 460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo.		2-fold embryo Ce	WBls:0000019
	The C. elegans life stage spanning 350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage.		bean embryo Ce	WBls:0000016
	The C. elegans life stage spanning 210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes.		late cleavage stage embryo Ce	WBls:0000014

4 Parents

Definition	Name	Synonym	Primary Identifier
inner labial socket cell.	IL socket cell		WBbt:0008418
embryonic cell	ABalaaappr		WBbt:0006029
portion of anterior ganglion of somatic nervous system that is anterior to the metacorpus of pharynx.	anterior ganglion (ant)		WBbt:0005372
	IL sensillum right		WBbt:0005122