WormMine: ExpressionPattern Expr16257

• Pattern: For lin-39 and mab-5, previous work reported their partially overlapping expression in the ventral cord motor neurons (MNs). In this study, we used two fosmid reporters wgIs18[lin39::EGFP] and wgIs27[mab-5::EGFP] to map their expression to the single-cell resolution among the 75 motor neurons (MNs), which include 54 cholinergic MNs, 19 GABAergic MNs, and 2 serotonergic MNs with stereotypical positions. These MNs can be further classified into eight neuron classes (DA, DB, VA, VB, AS, VC, DD, and VD). By crossing the GFP reporters with mCherry strains labelling cholinergic or GABAergic neurons in the ventral cord, we identified lin-39 expression in DA2-5, DB2-7, VA3-8, VB4-9, AS2-8, VC1-6, DD2-6, and VD3-12 and mab-5 expression in DA4-8, DB5-7, VA6-11, VB8-11, AS5-11, VC3-6, DD2-6, and VD2-12. Both lin-39 and mab-5 expression were generally weaker in more anterior MNs. Interestingly, for cholinergic MNs, mab-5 and lin-39 expression only overlapped in a set of mid-body MNs; MNs more anterior to this region expressed only lin-39 and MNs more posterior expressed only mab-5. For GABAergic MNs (DD and VD), however, lin-39and mab-5 expression overlapped entirely. Outside of the ventral nerve cord, lin-39 was expressed in AQR and AIYL/R in the head and AVM, SDQL/R, PDEL/R, and PVDL/R neurons along the body; mab-5 was expressed in the AVL in the head, SDQL in the mid-body region, and PQR neuron in the tail.
• Primary Identifier: Expr16257

61 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC4	lineage name: P6.aap	WBbt:0004617
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC5	lineage name: P7.aap	WBbt:0004613
Amphid interneuron	AIYL	lineage name: ABplpapaaap	WBbt:0003963
Amphid interneuron	AIYR	lineage name: ABprpapaaap	WBbt:0003961
Neuron, dopaminergic of postderid sensillum	PDEL	lineage name: V5L.paaa	WBbt:0004383
Neuron, dopaminergic of postderid sensillum	PDER	lineage name: V5R.paaa	WBbt:0004382
Ventral cord motor neuron, innervates ventral body muscles	VB9	lineage name: P8.aaap	WBbt:0004627
Ventral cord motor neuron, innervates ventral body muscles	VB5	lineage name: P4.aaap	WBbt:0004637
Ventral cord motor neuron, innervates ventral body muscles	VB6	lineage name: P5.aaap	WBbt:0004633
Ventral cord motor neuron, innervates ventral body muscles	VB7	lineage name: P6.aaap	WBbt:0004631
Ventral cord motor neuron, innervates ventral body muscles	VB8	lineage name: P7.aaap	WBbt:0004629
Ventral cord motor neuron, innervates ventral body muscles	VB4	lineage name: P3.aaap	WBbt:0004638
Neuron class of one sensory neuron, anterior ventral microtubule cell, touch receptor.	AVM	lineage name: QR.paa	WBbt:0003832
Ant. lateral interneuron, process projects into ring	SDQR	lineage name: QR.pap	WBbt:0004991
Ventral cord motor neurons, innervate dorsal muscles	DB4	lineage name: ABprpappapp	WBbt:0004843
Ventral cord motor neurons, innervate dorsal muscles	DA2	lineage name: ABplppapapa	WBbt:0004869
Ventral cord motor neurons, innervate dorsal muscles	DB5	lineage name: ABplpapappp	WBbt:0004842
Ventral cord motor neurons, innervate dorsal muscles	DB6	lineage name: ABplppaappp	WBbt:0004841
Ventral cord motor neurons, innervate dorsal muscles	DB7	lineage name: ABprppaappp	WBbt:0004840
Ventral cord motor neurons, innervate dorsal muscles	DB3	lineage name: ABprpaaaapp	WBbt:0004844
Ventral cord motor neurons, innervate dorsal muscles	DA3	lineage name: ABprppapapa	WBbt:0004867
Ventral cord motor neurons, innervate dorsal muscles	DA4	lineage name: ABplppapapp	WBbt:0004865
Ventral cord motor neurons, innervate dorsal muscles	DA5	lineage name: ABprppapapp	WBbt:0004863
Neuron, lateral process adjacent to excretory canal	PVDL	lineage name: V5L.paapa	WBbt:0004090
Neuron, lateral process adjacent to excretory canal	PVDR	lineage name: V5R.paapa	WBbt:0004088
Neuron class of one sensory neuron, basal body; not part of a sensillum, projects into ring.	AQR	lineage name: QR.ap	WBbt:0003927
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC6	lineage name: P8.aap	WBbt:0004611
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC1	lineage name: P3.aap	WBbt:0004621
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC2	lineage name: P4.aap	WBbt:0004619
Hermaphrodite specific ventral cord motor neuron innervates vulval muscles and ventral body muscles	VC3	lineage name: P5.aap	WBbt:0004618

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00003024	lin-39	C07H6.7	Caenorhabditis elegans

0 Life Stages