WormMine: AnatomyTerm WBbt:0003963

• Definition: Amphid interneuron
• Name: AIYL
• Primary Identifier: WBbt:0003963
• Synonym: lineage name: ABplpapaaap

1 Children

Definition	Name	Synonym	Primary Identifier
nucleus of pedigree ABplpapaaap	ABplpapaaap nucleus		WBbt:0001643

2 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Top 300 transcripts enriched in AIYL, AIYR according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:AIY
	Single-cell RNA-Seq cell group 112_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:112_0

184 Expression Patterns

• Primary Identifier: Expr4858
• Pattern: A-class motor neuron: enriched in embryo (2.8) and larva (3.1). Neuronal expression include: DA, VB, AS, DB, DD, HSN, VC4&5, AIY, head neurons. Also expressed in other cells: Muscle, intestine. Pan-neuronal: expressed in embryo; enriched in larva (1.5).

• Primary Identifier: Expr4693
• Remark: nsy-5 = T16H5.1.
• Pattern: A GFP reporter transgene with 5.8 kb of the nsy-5 promoter was expressed exclusively in sensory neurons and interneurons in the head and tail. The neurons that expressed nsy-5::GFP included AWC, ASH, AFD, ASI, ADL, ASK, BAG, AWB, and ADF (head sensory neurons); ADA, AIZ, RIC, AIY, and AIM (head interneurons); PHA and PHB (tail sensory neurons); and PVC and PVQ (tail interneurons). Expression began about halfway through embryogenesis, was strongest in late embryogenesis and the L1 larval stage, and faded thereafter. Adults maintained weak expression in several neurons, including ASH but not AWC.

• Primary Identifier: Expr4281
• Reporter Gene: [wrk-1::TM-gfp] translational fusion. wrk-1 expression was determined by means of a reporter construct (wrk1::TM::gfp), in which 4 kb of sequences upstream of the ATG start codon, all exons, and the first three introns of the wrk-1 locus were fused in frame to gfp. This construct is able to rescue the phenotype of wrk-1 mutant animals. See Transgene otEx2389. [wrk-1::gfp] transcriptional fusion in which 4 kb of sequences upstream of the ATG start codon was fused to GFP. See Transgene otEx203 [wrk-1::gfp] translational fusion. See Transgene otEx2522.
• Pattern: The wrk-1 gene is expressed in ventral midline cells, namely in the eMNs. Additional expression is observed in a subset of head neurons, including interneurons (AIY class), sensory neurons (ASI class), and head motoneurons (SMDV/D class), and glial-type sheath and socket cells. Outside the nervous system, the most prominent sites of wrk-1 expression include the intestine, excretory gland cell, distal tip cell, and coelomocytes.

• Primary Identifier: Expr4525
• Pattern: Expressed in ASER, ASIL/R, PVT, URXL/R, AIYL/R, intestine.

• Primary Identifier: Expr10072
• Remark: Figure 7
• Pattern: Expressed in AIY.

• Primary Identifier: Expr10071
• Remark: Figure 7
• Pattern: Expressed in AIY.

• Primary Identifier: Expr15649

• Primary Identifier: Marker51
• Remark: Picture: N.A. Reporter gene fusion type not specified.
• Pattern: Expressed in AIY neurons

• Primary Identifier: Marker52
• Remark: Picture: N.A. Reporter gene fusion type not specified.
• Pattern: Expressed in AIY and AIA neurons.

• Primary Identifier: Marker53
• Remark: Picture: N.A. Reporter gene fusion type not specified.
• Pattern: Expressed in AIY neurons.

• Primary Identifier: Marker54
• Remark: Picture: N.A. Reporter gene fusion type not specified.
• Pattern: Expressed in AIY neurons.

• Primary Identifier: Marker49
• Remark: Picture: N.A. Reporter gene fusion type not specified.
• Pattern: Expressed in anterior neurons, including AIY, AIZ, RID, M5, ASI, and labial sensory neurons, VNC motorneurons, midbody neurons HSN, CAN, and PVM, tail neurons DVB, DVC, and PDB, and the nonneuronal excretory cell, uterine muscles. -- according to pers. comm. from Oliver Hobert.

• Primary Identifier: Marker22
• Remark: Picture: Figure 1E. Reporter gene fusion type not specified.
• Pattern: Expressed in AIY neurons.

• Primary Identifier: Marker66
• Remark: Picture: N.A. Reporter gene fusion type not specified.
• Pattern: Marker for the AIY interneurons.

• Primary Identifier: Expr10065
• Remark: Figure 7
• Pattern: Expressed in AIY.

• Primary Identifier: Expr10066
• Remark: Figure 7
• Pattern: Expressed in AIY.

• Primary Identifier: Expr10090
• Remark: Table S1A.
• Pattern: Expressed in AIY.

• Primary Identifier: Expr13039

• Primary Identifier: Expr10092
• Remark: Table S1A.
• Pattern: Expressed in AIY.

• Primary Identifier: Expr15558

• Primary Identifier: Expr15560

• Primary Identifier: Expr15571

• Primary Identifier: Expr15572

• Primary Identifier: Expr15573

• Primary Identifier: Expr15579

• Primary Identifier: Expr15586

• Primary Identifier: Expr15651

• Primary Identifier: Expr15652

• Primary Identifier: Expr15589

• Primary Identifier: Expr13158

11 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003
	The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.		fully-elongated embryo Ce	WBls:0000021
	The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over.		elongating embryo Ce	WBls:0000015
	The C. elegans life stage spanning 290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastrulation and is enclosing.		enclosing embryo Ce	WBls:0000013
	The C. elegans life stage spanning 0-350min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 560 cells. From start of first cleavage until cleavage is over.		proliferating embryo Ce	WBls:0000004
	The C. elegans life stage spanning 520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage.		3-fold embryo Ce	WBls:0000020
	The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo.		1.5-fold embryo Ce	WBls:0000018
	The C. elegans life stage spanning 390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo.		comma embryo Ce	WBls:0000017
	The C. elegans life stage spanning 460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo.		2-fold embryo Ce	WBls:0000019
	The C. elegans life stage spanning 350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage.		bean embryo Ce	WBls:0000016
	The C. elegans life stage spanning 210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes.		late cleavage stage embryo Ce	WBls:0000014

5 Parents

Definition	Name	Synonym	Primary Identifier
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
embryonic cell	ABplpapaaa		WBbt:0006679
ventral ganglion, posterior part.	ventral ganglion (post)		WBbt:0005264
cell that exists in and is part of an embryo.	embryonic cell		WBbt:0007028
Neuron class of two interneurons, is one of the main classes of integrating neuron for the receptors of the amphid sensilla.	AIY		WBbt:0005413