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Expression Pattern :

Pattern  Expression of mig-2::GFP was first detected in early embryos, prior to the onset of morphogenesis (~300 min after first cell cleavage). At this time, expression was seen in nearly every cell with the exception of the intestine. At hatching, many but not all cell types expressed the fusion protein. In particular, mig-2::GFP was expressed in cells that undergo long-range migration during embryogenesis, such as the neurons HSN, CAN, and ALM. Expression was quite strong in the Q cells and their descendants during their migrations in the first larval stage. Expression in these neurons persisted through development. Many mesodermal cells, such as the embryonic migratory cells Z1 and Z4, also expressed mig-2::GFP, although one migratory mesodermal cell, M, did not. Weaker mig-2::GFP expression was also seen in many nonmigratory neurons and epidermal cells; however, no expression was detected in the intestine or germ line. In older larvae and adult hermaphrodites, expression was seen in the vulva, distal tip cells of the gonad, and the sex myoblasts and their descendants. Similar patterns of expression were seen in two additional independently isolated transgenic lines. Primary Identifier  Expr1463
Remark  Lineage expression: sex myoblasts and their descandents. Subcellular Localization  Throughout development, the fusion protein was clearly localized to the cell periphery (plasma membrane) in most cell types, and no asymmetric subcellular localization was reliably detected. Interestingly, some mig-2::GFP-expressing cells exhibited cytoplasmic as well as membrane-localized staining. These were the HSN neuron, the distal tip cells, the gonadal anchor cell, and the granddaughters of the Q cells.
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29 Anatomy Terms

Definition Name Synonym Primary Identifier
Posterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad posterior distal tip cell gon herm dtc P WBbt:0004506
Anterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad anterior distal tip cell gon herm dtc A WBbt:0004520
Herm. specific motor neurons (die in male embryo), innervate vulval muscles, serotonergic HSNL lineage name: ABplapppappa WBbt:0004758
Herm. specific motor neurons (die in male embryo), innervate vulval muscles, serotonergic HSNR lineage name: ABprapppappa WBbt:0004757
adult vulval toroid cell, F, formed by fusion of precursors of lineage names P6.papl, P6.papr, P6.ppal and P6.ppar. vulF   WBbt:0006768
adult vulval toroid cell, E, formed by fusion of precursors of lineage names P6.paal, P6.paar, P6.pppl and P6.pppr. vulE   WBbt:0006767
Anterior lateral microtubule cell, touch receptor ALML lineage name: ABarppaappa WBbt:0003954
Anterior lateral microtubule cell, touch receptor ALMR lineage name: ABarpppappa WBbt:0003953
Process runs along excretory canal, no synapses, essential for survival CANL lineage name: ABalapaaapa WBbt:0004949
Process runs along excretory canal, no synapses, essential for survival CANR lineage name: ABalappappa WBbt:0004947
adult vulval toroid cell, C, formed by fusion of precursors of lineage names P5.ppal, P5.ppar, P7.papl and P7.papr. vulC   WBbt:0006765
adult vulval toroid cell, B1, formed by fusion of precursors of lineage names P5.papa and P7.ppap. vulB1   WBbt:0006763
adult vulval toroid cell, B2. vulB2   WBbt:0006764
adult vulval toroid cell, D, formed by fusion of precursors of lineage names P5.ppp and P7.paa. vulD   WBbt:0006766
adult vulval toroid cell, A, formed by fusion of precursors of lineage names P5.paaa, P5.paap, P7.pppa and P7.pppp vulA   WBbt:0006762
Postembryonic neuroblast, migrates posteriorly. QL lineage name: ABplapapaaa WBbt:0004056
Somatic gonad precursor cell Z1 lineage name: MSpppaap WBbt:0004577
Somatic gonad precursor cell Z4 lineage name: MSappaap WBbt:0004574
Postembryonic neuroblast, migrates anteriorly. QR lineage name: ABprapapaaa WBbt:0004054
post-embryonic cell of pedigree QR.pa QR.pa   WBbt:0007282
post-embryonic cell of pedigree QR.p QR.p   WBbt:0007281
post-embryonic cell of pedigree QR.aa QR.aa   WBbt:0007280
post-embryonic cell of pedigree QR.a QR.a   WBbt:0007279
post-embryonic cell of pedigree QR.pp QR.pp   WBbt:0007283
post-embryonic cell of pedigree QL.pa QL.pa   WBbt:0007277
post-embryonic cell of pedigree QL.p QL.p   WBbt:0007276
post-embryonic cell of pedigree QL.aa QL.aa   WBbt:0007275
post-embryonic cell of pedigree QL.a QL.a   WBbt:0007274
post-embryonic cell of pedigree QL.pp QL.pp   WBbt:0007278

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003239 mig-2 C35C5.4 Caenorhabditis elegans

1 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  All C. elegans development stages, including embryo, larva and adult stage. all stages Ce WBls:0000002