WormMine

WS295

Intermine data mining platform for C. elegans and related nematodes

Expression Pattern :

Pattern  Expressed on the surface of motile cells and pioneering neurons whose migrations are affected in unc-40 mutants. UNC-40/GFP becomes detectable on the surface of all cells at the onset of gastrulation (~100 min after first cleavage), and then gradually decreases. By the end of gastrulation (~290 min), the protein is barely detectable on all cells. In the neurula (~400 min), UNC-40/GFP is highly expressed on ventral cord motorneurons, including cell bodies and axons, undergoing axonogenesis. Additional neurons express UNC-40/GFP soon after, but are difficult to identify in the elongating neurula. This expression generally persists into the first larval stage and beyond, allowing unambiguous identification of most cells. Similar expression patterns were observed using unc-40 upstream regulatory sequences to direct cytoplasmic expression of soluble GFP. In first stage larvae, ventral epidermoblasts P1/2 to P11/12 (Pn cells) express UNC-40/GFP as they undergo planar movements within the epithelium. Similarly, neuroblasts QL and QR and their descendants express UNC-40/GFP as they migrate longitudinally along the epidermis. In second stage and later larvae, the distal tip cells of hermaphrodites express UNC-40/GFP as they migrate along the body wall. Primary Identifier  Expr1601
Remark  Reporter gene fusion type not specified. Subcellular Localization  cytoplasmic expression
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63 Anatomy Terms

Definition Name Synonym Primary Identifier
Anterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad anterior distal tip cell gon herm dtc A WBbt:0004520
Posterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad posterior distal tip cell gon herm dtc P WBbt:0004506
Neuron class of thirteen motoneurons, with cell bodies in the ventral cord, which innervate ventral muscles. Each cell has an anteriorly directed process emanating from its cell body. VD neuron   WBbt:0005303
Neuron class of six motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles. Each cell has a short, posteriorly directed and a longer, anteriorly directed process emanating from its cell body. The anterior process has a branch, which leaves the ventral cord as a commissure and runs round to the dorsal cord. DD neuron   WBbt:0005270
Neuron class of seven motoneurons that innervate dorsal muscles and have cell bodies in the ventral cord. DB neuron   WBbt:0005274
Neuron class of twelve motoneurons, distributed along the ventral cord, which innervate ventral body muscles. VA neuron   WBbt:0005339
Neuron class of eleven motoneurons, distributed along the ventral cord, which innervate ventral body muscles. VB neuron   WBbt:0005336
Neuron class of nine ventral cord motor neuron, innervates dorsal muscle. DA neuron   WBbt:0005278
Neuron class of eleven motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles. AS neuron   WBbt:0005334
Neuron class of six motoneurons in the ventral cord, which innervate ventral body muscles and the vm2 muscles of the vulva. VC neuron   WBbt:0005304
A blast cell from which a neuron develops. neuroblast   WBbt:0008594
The tenth (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P10   WBbt:0006779
The ninth (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P9   WBbt:0006778
Postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1 P12 lineage name: ABprapappa WBbt:0004409
Postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1 P11 lineage name: ABplapappa WBbt:0004410
The third (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P3   WBbt:0006772
The second (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P2   WBbt:0006771
The first (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P1 P1 post-embryonic blast cell WBbt:0006770
The seventh (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P7   WBbt:0006776
The sixth (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P6   WBbt:0006775
The fifth (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P5   WBbt:0006774
The fourth (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P4   WBbt:0006773
The eighth (count from anterior-most) of twelve postembryonic blast cells for ventral cord motorneurons, ventral hypodermis, vulva, male preanal ganglion; ventral hypodermis in L1. P8   WBbt:0006777
Postembryonic neuroblast, migrates posteriorly. QL lineage name: ABplapapaaa WBbt:0004056
Postembryonic neuroblast, migrates anteriorly. QR lineage name: ABprapapaaa WBbt:0004054
post-embryonic cell of pedigree QR.a QR.a   WBbt:0007279
post-embryonic cell of pedigree QR.pp QR.pp   WBbt:0007283
post-embryonic cell of pedigree QR.pa QR.pa   WBbt:0007282
post-embryonic cell of pedigree QR.p QR.p   WBbt:0007281
post-embryonic cell of pedigree QR.aa QR.aa   WBbt:0007280

1 Genes

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00006776 unc-40 T19B4.7 Caenorhabditis elegans

7 Life Stages

Remark Definition Other Name Public Name Primary Identifier
  The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo. fully-elongated embryo Ce WBls:0000021
  The C. elegans life stage spanning 100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation. gastrulating embryo Ce WBls:0000010
  The C. elegans life stage spanning 390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo. comma embryo Ce WBls:0000017
  The C. elegans life stage spanning 460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo. 2-fold embryo Ce WBls:0000019
  The C. elegans life stage spanning 520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage. 3-fold embryo Ce WBls:0000020
  The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo. 1.5-fold embryo Ce WBls:0000018
  A developemental life stage of the nematode Caenorhabditis elegans that occurs from egg hatching until death. postembryonic Ce WBls:0000022