WormMine: AnatomyTerm WBbt:0003985

• Definition: Amphid interneuron
• Name: AIBL
• Primary Identifier: WBbt:0003985
• Synonym: lineage name: ABplaapappa

1 Children

Definition	Name	Synonym	Primary Identifier
nucleus of pedigree ABplaapappa	ABplaapappa nucleus		WBbt:0001637

2 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Top 300 transcripts enriched in AIBL, AIBR according to single cell RNAseq.	Top 300 enriched transcripts were determined by log2.ratio of the tpm in the cell type vs the tpm in the other cells * the log2 of the cell.type tpm.	WBPaper00061340:AIB
	Single-cell RNA-Seq cell group 97_0 expressed in neuron.	scVI 0.6.0	WBPaper00065841:97_0

70 Expression Patterns

• Primary Identifier: Expr15649

• Primary Identifier: Expr15558

• Primary Identifier: Expr15567

• Primary Identifier: Expr15571

• Primary Identifier: Expr15572

• Primary Identifier: Expr15573

• Primary Identifier: Expr15579

• Primary Identifier: Expr15586

• Primary Identifier: Expr15651

• Primary Identifier: Expr15652

• Primary Identifier: Expr15589

• Primary Identifier: Expr13158

• Primary Identifier: Expr15591

• Primary Identifier: Expr13164
• Pattern: For lgc-38, all expressing cells shown are observed with the 3.5 kb reporter fusion, except for OLL, which only expresses the 3.9 kb fusion; URA expresses both.

• Primary Identifier: Expr15598

• Primary Identifier: Expr8850
• Remark: Picture: Fig 3.
• Pattern: Neuronal Expression: AVA, AVB, AVE, PVC, AIB, AUA, AVG, RIB, RIC, SAA, SIA, SIB, RIF, RIM, RMD, RME, SMD, DA, DB, VA, VB, M5, NSM, MC, I3, MI?. Non-neuronal Expression: rectal epithelium, body wall muscle, spermethecae, vulva muscle.

• Primary Identifier: Expr15604

• Primary Identifier: Expr14590
• Pattern: Embryonic expression of exc-7 was first observed at the bean stage. By reverse lineaging with use of SIMI-Biocell software, we confirm the identity of one of the expressing cells at this stage as the excretory canal cell. In L1 animals, broad expression in the head, ventral nerve cord (VNC), and tail was observed. In young adults, expression is notably observed in vulva cells. In the nervous system specifically, expression is observed in many neurons throughout the body, but unlike Drosophila Elav, exc-7::gfp it is not panneuronally expressed. We confirmed previously reported expression in cholinergic VNC MNs, but absence of GABAergic VNC MNs, consistent with previous reports (Fujita et al., 1999; Loria et al., 2003) and consistent with exc-7 functioning in cholinergic, but not GABAergic neurons to control alternative splicing (Norris et al., 2014). exc-7::gfp is also expressed in some non-neuronal cell types, including muscle and hypodermis, but not in the gut. A previous report showed that exc-7 is only transiently and weakly expressed in the excretory cell, which, based on exc-7's excretory mutant phenotype, has puzzled researchers (Fujita et al., 2003). We find that the gfp tagged exc-7 locus is strongly and continuously expressed in the excretory canal cell.

• Primary Identifier: Expr15608

• Primary Identifier: Expr11375
• Pattern: eat-4 is expressed in 78 of the 302 neurons of the adult hermaphrodite, which fall into 38 neuron classes (out of a total of 118 anatomically defined neuron classes in the hermaphrodite). Most of these neurons are either sensory- or interneurons. Only two motorneurons utilize glutamate; both are located in the pharynx.

• Primary Identifier: Expr15611

• Primary Identifier: Expr1824
• Remark: Cells expressing TAX-6 were visualized using several tax-6::gfp fusion genes. The expression of tax-6 is under diverse transcriptional controls. Reporter gene fusion type not specified. pAK43 is a larger transgene that should include all promoter regions for tax-6 transcription, since another gene is encoded just upstream of this region and tax-6 mRNA does not seem to be derived from a polycistronic transcript.
• Pattern: When introduced into wildtype animals, pAK43 drove TAX-6 expression in many sensory neurons, as well as interneurons including AIY and AIZ, and most, if not all, muscle cells. pAK43 is expressed in muscle, AIB, AIY, AIZ, RIA, RIB, RIS, RIM, ASI, ADF, ASH, ASK, ADL, AUA, PHA, PHB, AVE. It is also expressed in AFD, ASE, AWA, AWC, AVK, AIM, RMDV, AVA.

• Primary Identifier: Expr15363

• Primary Identifier: Expr16053
• Pattern: A functional transcriptional reporter for CKR-1 revealed strong expression in many neurons and weak expression in the intestine. In the nervous system, ckr-1 expresses in the head and ventral cord neurons. CKR-1-expressing neurons include head motor neurons SMD and RME , interneurons AIB and RIM, peptidergic neurons RIS, and body motor neurons A, B, and D.

• Primary Identifier: Expr8844
• Remark: Picture: Fig 3.
• Pattern: Neuronal Expression: ASI, ASJ, AVB, AVE, PVC, AIB, AIN, DA, DB, M2, NSM. Non-neuronal Expression: pharynx, GLR cells.

• Primary Identifier: Expr7948
• Remark: Picture: Figure 1 A, B.
• Pattern: GFP fluorescence was observed in paired neurons situated in the head region around the posterior pharyngeal bulb. The unique morphology suggested that expression was in the AIB interneuron pair. Based on cell position, DiI staining, costaining, and morphology authors concluded that npr-9 is expressed in the AIB interneuron. No GFP fluorescence was noted in somatic gonad tissue, vulval muscle, body wall, and inner labial neurons. An identical pattern of head neuron GFP expression was noted during all larval stages (L1, L2, L3, and L4) and in hermaphrodite adults. There was no GFP expression detected in embryos.

• Primary Identifier: Expr8669
• Remark: Picture: N.A.
• Pattern: Expression in the alimentary canal: Strong and consistent expression in pm1. inx-1 starts to be expressed in a few head neurons including AIB (brightest) and AIY (fainter; expression ends in L2) by three-fold stage.

• Primary Identifier: Expr15570

• Primary Identifier: Expr15644

• Primary Identifier: Expr15648

12 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003
	The C. elegans life stage spanning 620-800min(hatch) after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. A stage after elongation is over. The last stage of embryogenesis. Also called pre-hatched embryo, late embryo or morphogenetic embryo.		fully-elongated embryo Ce	WBls:0000021
	The C. elegans life stage spanning 350-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The stage that embryo starts elongation until elongation is over.		elongating embryo Ce	WBls:0000015
	The C. elegans life stage spanning 290-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage when embryo just finished gastrulation and is enclosing.		enclosing embryo Ce	WBls:0000013
	The C. elegans life stage spanning 100-290min after first cleavage at 20 Centigrade. Proliferate from 28 cells to 421 cells. Referring to the whole period of gastrulation.		gastrulating embryo Ce	WBls:0000010
	The C. elegans life stage spanning 0-350min after first cleavage at 20 Centigrade. Proliferate from 1 cell to 560 cells. From start of first cleavage until cleavage is over.		proliferating embryo Ce	WBls:0000004
	The C. elegans life stage spanning 520-620min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and tripple fold. A stage between 2-fold embryo and fully-elongated embryo. Also called pretzel embryo or pretzel stage.		3-fold embryo Ce	WBls:0000020
	The C. elegans life stage spanning 420-460min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and fold back 50%. A stage between comma embryo and 2-fold embryo.		1.5-fold embryo Ce	WBls:0000018
	The C. elegans life stage spanning 390-420min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo looks like a comma. A stage between bean embryo and 1.5-fold embryo.		comma embryo Ce	WBls:0000017
	The C. elegans life stage spanning 460-520min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. The shape of embryo is elongated and double fold. A stage between 1.5-fold embryo and 3-fold embryo.		2-fold embryo Ce	WBls:0000019
	The C. elegans life stage spanning 350-390min after first cleavage at 20 Centigrade. Cell number remains at ~560 cells, with some new cells generated and some cells go through programmed cell death. Emrbyo elongation started but have not formed comma shape yet. The shape of embryo looks like a lima bean. A stage right before comma embryo. Also called lima embryo or lima bean stage.		bean embryo Ce	WBls:0000016
	The C. elegans life stage spanning 210-350min after first cleavage at 20 Centigrade. Proliferate from 421 cells to 560 cells. The stage before the fast cleavage of cells finishes.		late cleavage stage embryo Ce	WBls:0000014

5 Parents

Definition	Name	Synonym	Primary Identifier
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
cell that exists in and is part of an embryo.	embryonic cell		WBbt:0007028
embryonic cell	ABplaapapp		WBbt:0006586
Neuron class of two interneurons with cell bodies situated in the lateral ganglia.	AIB		WBbt:0006813
neuron type, cell body located in left lateral ganglion.	lateral ganglion left neuron		WBbt:0005102