WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

Gene :

WormBase Gene ID  ? WBGene00006876 Gene Name  vab-10
Sequence Name  ? ZK1151.1 Brief Description  vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP.
Organism  Caenorhabditis elegans Automated Description  Predicted to enable actin filament binding activity and structural molecule activity. Involved in epidermis morphogenesis. Located in apical plasma membrane; basal plasma membrane; and hemidesmosome. Expressed in several structures, including gonad; intestinal lumen; nerve ring; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex; hereditary sensory and autonomic neuropathy type 6; and lissencephaly 9 with complex brainstem malformation. Is an ortholog of human DST (dystonin).
Biotype  SO:0001217 Genetic Position  I :9.6157 ±0.240987
Length (nt)  ? 57568
Quick Links:
 

1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Synonyms

Value
WBGene00006876

Genomics

14 Transcripts

WormMine ID Sequence Name Length (nt) Chromosome Location
Transcript:ZK1151.1j.1 ZK1151.1j.1 15137   I: 11747424-11792066
Transcript:ZK1151.1c.1 ZK1151.1c.1 15218   I: 11747428-11792118
Transcript:ZK1151.1o.1 ZK1151.1o.1 10353   I: 11747762-11760542
Transcript:ZK1151.1n.1 ZK1151.1n.1 10695   I: 11747762-11762201
Transcript:ZK1151.1l.1 ZK1151.1l.1 15180   I: 11747762-11783939
Transcript:ZK1151.1m.1 ZK1151.1m.1 14841   I: 11747762-11783939
Transcript:ZK1151.1k.1 ZK1151.1k.1 14460   I: 11747762-11792066
Transcript:ZK1151.1d.1 ZK1151.1d.1 10182   I: 11764837-11792066
Transcript:ZK1151.1f.1 ZK1151.1f.1 9933   I: 11764837-11792066
Transcript:ZK1151.1h.1 ZK1151.1h.1 10275   I: 11764837-11792066
Transcript:ZK1151.1e.1 ZK1151.1e.1 9995   I: 11764837-11792125
Transcript:ZK1151.1b.1 ZK1151.1b.1 10731   I: 11764837-11797947
Transcript:ZK1151.1a.1 ZK1151.1a.1 11085   I: 11764837-11804991
Transcript:ZK1151.1i.1 ZK1151.1i.1 4725   I: 11773130-11783939
 

Other

14 CDSs

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:ZK1151.1c ZK1151.1c 14832   I: 11747762-11747801
CDS:ZK1151.1n ZK1151.1n 10695   I: 11747762-11747801
CDS:ZK1151.1m ZK1151.1m 14841   I: 11747762-11747801
CDS:ZK1151.1f ZK1151.1f 9933   I: 11764837-11770713
CDS:ZK1151.1e ZK1151.1e 9936   I: 11764837-11770713
CDS:ZK1151.1b ZK1151.1b 10716   I: 11764837-11770713
CDS:ZK1151.1a ZK1151.1a 11085   I: 11764837-11770713
CDS:ZK1151.1i ZK1151.1i 4494   I: 11773361-11773513
CDS:ZK1151.1d ZK1151.1d 10182   I: 11764837-11770713
CDS:ZK1151.1h ZK1151.1h 10275   I: 11764837-11770713
CDS:ZK1151.1j ZK1151.1j 14799   I: 11747762-11747801
CDS:ZK1151.1k ZK1151.1k 14460   I: 11747762-11747801
CDS:ZK1151.1l ZK1151.1l 15180   I: 11747762-11747801
CDS:ZK1151.1o ZK1151.1o 10353   I: 11747762-11747801

65 RNAi Result

WormBase ID
WBRNAi00089769
WBRNAi00004911
WBRNAi00027038
WBRNAi00027039
WBRNAi00052233
WBRNAi00052234
WBRNAi00059146
WBRNAi00059148
WBRNAi00059149
WBRNAi00000061
WBRNAi00080609
WBRNAi00080610
WBRNAi00115201
WBRNAi00109217
WBRNAi00116147
WBRNAi00027035
WBRNAi00027036
WBRNAi00099872
WBRNAi00025583
WBRNAi00004108
WBRNAi00022511
WBRNAi00071651
WBRNAi00071742
WBRNAi00090806
WBRNAi00109605
WBRNAi00081405
WBRNAi00035367
WBRNAi00100893
WBRNAi00071061
WBRNAi00071060

1000 Allele

Public Name
gk962706
gk963849
gk962859
gk964175
gk390081
gk351797
gk465981
gk563382
gk671618
gk371751
gk653127
gk682974
gk775804
gk327305
gk868632
gk569784
gk815811
gk326183
gk888880
gk478807
gk866568
gk801211
gk869524
gk517201
gk872351
gk651537
gk708695
gk698495
gk606166
gk626480

1 Chromosome

WormBase ID Organism Length (nt)
I Caenorhabditis elegans 15072434  

1 Chromosome Location


Feature . Primary Identifier
Start End Strand
WBGene00006876 11747424 11804991 -1

4 Data Sets

Name URL
WormBaseAcedbConverter  
GO Annotation data set  
C. elegans genomic annotations (GFF3 Gene)  
Panther orthologue and paralogue predictions  

0 Downstream Intergenic Region

294 Expression Clusters

Regulated By Treatment Description Algorithm Primary Identifier
  oocyte proteins identified by two or more unique peptides during proteomics study. In the pooled data set, 1453 C. elegans proteins were identified with a probability >= 0.9 according to ProteinProphet, of which 1165 proteins were identified by more than one unique peptide. WBPaper00038289:oocyte_protein
  Transcripts of coding genes that showed significantly decreased expression in muscle. DESeq2 (version 1.24.0). Transcripts with a false-discovery rate adjusted p-value less than 0.05 were considered significantly differentially expressed. WBPaper00062325:muscle_depleted_coding-RNA
  Transcripts expressed in neuronal cells, by analyzingfluorescence-activated cell sorted (FACS) neurons. DESeq. False discovry rate (FDR) < 0.1. WBPaper00048988:neuron_expressed
  Genes that showed expression levels higher than the corresponding reference sample (embryonic 24hr reference). A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes. WBPaper00037950:all-neurons_L1-larva_expressed
adult vs dauer larva Transcripts that showed differential expression in adult vs dauer lava in N2 animals at 20C. N.A. WBPaper00050488:adult_vs_dauer_regulated_N2_20C
  mRNAs that showed decreased expression in 1 cell mebryo comparing to in oocyte, according to RNAseq analysis. Gaussian error propagation. As cutoff for the up-regulated genes authors used log2 fold change > 1 and P < 0.05 and as cutoff for the down-regulated genes authors used log2 fold change < -1 and P < 0.05. WBPaper00045420:fertilization_downregulated_transcript
  TGF- Dauer pathway adult transcriptional targets. Results obtained by comparing the microarray results of the dauer-constitutive mutants daf-7(e1372), daf-7(m62), and daf-1(m40) with dauer-defective mutants daf-3(mgDf90), daf-5(e1386), and daf-7(e1372);daf-3(mgDf90) double mutants at the permissive temperature, 20C, on the first day of adulthood. SAM WBPaper00031040:TGF-beta_adult_upregulated
  Genes that showed expression levels higher than the corresponding reference sample (embryonic 24hr reference). A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes. WBPaper00037950:AVE-neuron_L1-larva_expressed
Osmotic stress Transcripts that showed significantly altered expression with 500 mM salt (NaCl) vs 100 mM salt when food was present DESeq(version 1.10.1), FDR < 0.05. WBPaper00050726:OsmoticStress_regulated_Food
  Transcripts that showed significantly increased expression in csr-1a(tor159) comparing to in N2 at 25C. DESeq2, fold change > 2, p-value < 0.05. WBPaper00061753:csr-1(tor159)_upregulated_25C
  Genes that showed expression levels higher than the corresponding reference sample (embryonic 24hr reference). A Mann-Whitney U test with an empirical background model and FDR correction for multiple testing was used to detect expressed transcripts (Benjamini and Hochberg 1995). Genes and TARs with an FDR <= 0.05 were reported as expressed above background. Authors detected differentially expressed transcripts using a method based on linear models. Genes and TARs were called differentially expressed if the FDR was <= 0.05 and the fold change (FC) >= 2.0. To more strictly correct for potential false-positives resulting from multiple sample comparisons, authors divided individual FDR estimates by the number of samplesor sample comparisons, respectively. This resulted in an adjusted FDR of 1.3 * 0.0001 for expression above background and of 7.4 * 0.0001 for differential expression. Authors called genes selectively enriched in a given tissue if they met the following requirements: (1) enriched expression in a given tissue (FDR <= 0.05 and FC >= 2.0), (2) fold change versus reference among the upper 40% of the positive FC range observed for this gene across all tissues, and (3) fold-change entropy among the lower 40% of the distribution observed for all genes. WBPaper00037950:bodywall-muscle_L1-larva_expressed
  Transcripts that showed significantly increased expression glp-1(e2141); TU3401 animals comparing to in TU3401 animals. Fold change > 2, FDR < 0.01. WBPaper00065993:glp-1(e2141)_upregulated
  Transcripts that showed significantly increased expression after animals were treated with 50uM Rifampicin from day 1 to day 3 adult hermaphradite. DESeq2(v1.14.1), fold change > 2, p-value < 0.05 WBPaper00055354:Rifampicin_upregulated
  Transcripts that showed significantly higher expression in somatic gonad precursor cells (SGP) vs. head mesodermal cells (hmc). DESeq2, fold change >= 2, FDR <= 0.01. WBPaper00056826:SGP_biased
  Coexpression clique No. 60, 176662_at-Y53F4B.16, on the genome-wide coexpression clique map for the nematode GPL200 platform. All available microarray datasets for the GPL200 platform (Affymetrix C. elegans Genome Array) were obtained from the GEO repository. This included 2243 individual microarray experiments. These were normalized against each other with the software RMAexpress (Bolstad, 2014). Based on these normalized values, Pearsons correlation coefficients were obtained for each probe-probe pair of the 22,620 probes represented on this array type. The resulting list of correlation coefficients was then ranked to generate the ranked coexpression database with information on each probe represented on the GPL200 platform. WBPaper00061527:176662_at-Y53F4B.16
  Proteins interacting with NHR-49-GFP according to co-IP and LC-MS. N.A. WBPaper00064071:NHR-49_interacting
  Transcripts expressed in the epithelial tissues surrounding the pharynx that includes the arcade and intestinal valve (AIV) cells, according to PAT-Seq analysis using Pbath-15-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:arcade_intestinal-valve_expressed
  Transcripts expressed in body muscle, according to PAT-Seq analysis using Pmyo-3-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:body-muscle_expressed
  Transcripts that showed significantly decreased expression at 5-days-post L4 adult N2 hermaphrodites comparing to 1-day-post L4 adult N2 hermaphrodites. DESeq2, fold change > 2, FDR < 0.05 WBPaper00065835:Day5_vs_Day1_downregulated
  Transcripts expressed in GABAergic neuron, according to PAT-Seq analysis using Punc-47-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:GABAergic-neuron_expressed
  Transcripts expressed in hypodermis, according to PAT-Seq analysis using Pdpy-7-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:hypodermis_expressed
  Transcripts expressed in intestine, according to PAT-Seq analysis using Pges-1-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:intestine_expressed
  Transcripts expressed in NMDA neuron, according to PAT-Seq analysis using Pnmr-1-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:NMDA-neuron_expressed
  Transcripts expressed in pharynx, according to PAT-Seq analysis using Pmyo-2-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:pharynx_expressed
  Transcripts expressed in seam cells, according to PAT-Seq analysis using Pgrd-10-GFP-3XFLAG mRNA tagging. Cufflinks FPKM value >=1. WBPaper00050990:seam_expressed
  Transcripts that showed significantly decreased expression in day 3 adult hermaphrodite comparing to in L4 larva glp-1(e2141) animals. Fold change > 2, FDR < 0.05 WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
Bacteria infection: Photorhabdus luminescens Genes down-regulated in animals infected with Photorhabdus luminescens compared to the E. coli OP50 control after 24h of infection. MAANOVA and BRB-Array-Tools. WBPaper00030985:Photorhabdus_luminescens_downregulated
  Transcripts expressed in vulva. FPKM >= 1. WBPaper00064122:vulva_transcriptome
Bacteria infection: Bacillus thuringiensis mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 10 mix) vs BT407 12h), according to RNAseq. Cuffdiff, ajusted p-value < 0.01. WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
Bacteria infection: Bacillus thuringiensis mRNAs that showed significantly decreased expression after pathogenic bacteria Bacillus thuringiensis infections comparing to non pathogenic BT (BT247(1 to 2 mix) vs BT407 6h), according to RNAseq. Cuffdiff, ajusted p-value < 0.01. WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h

23 Expression Patterns

Remark Reporter Gene Primary Identifier Pattern Subcellular Localization
    Expr1162570 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015  
    Expr9644 mRNAs for VAB-10A1 and VAB-10B1, which include the entire N-terminal ABD, could be transcribed from upstream of exon 1, whereas the mRNAs for VAB-10A2 and VAB-10B2, which lack the N-terminal half of the ABD, could be transcribed from downstream of exon 5. The vab-10A1 and B1 are expressed in the distal tip cells, pharynx and body wall muscles, whereas the vab-10A2 and B2 are expressed in epidermis.  
    Expr9645 Both anti-VAB-10N and anti-VAB-10B detected signals in wild-type DTCs. Anti-VAB-10A failed to reveal signals even in wild-type DTCs. Although anti-VAB-10N uniformly stained the cytoplasm of DTCs in whole-mount worm preparations, it detected discontinuous filamentous structures in the dissected gonads. These results suggest that the filamentous antigen localization may be susceptible to fixative conditions. Immunohistochemical analysis also revealed that anti-VAB-10A stained fibrous organelles in the epidermis, and anti-VAB-10B detected reciprocal circumferential bands in the epidermis. We also detected signals in the pharynx and body wall muscle using anti-VAB-10B and anti-VAB-10N.  
    Expr2023970 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr2023969 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr2036081 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr1032916 Tiling arrays expression graphs  
These patterns are specific because MH5 and polyclonal VAB-10A antibodies failed to detect a signal in vab-10(h1356) and vab-10Adeficient embryos. Likewise, VAB-10B antibodies could only detect a weak signal in the intestine and pharynx of mid-staged vab-10B(mc44) and vab-10(h1356) embryos. Although it cannot be excluded that VAB-10B antisera recognize a cross-reacting protein, VAB-10B is likely to be expressed in the pharynx and the intestine because surviving vab-10B(mc44) larvae had an abnormal intestine.   Expr2601 In embryos, VAB-10A and VAB-10B antibodies first detected a signal at the basal and apical plasma membranes of dorsal and ventral epidermal cells, soon after the onset of differentiation. As these cells became thinner during morphogenesis, staining appeared as four longitudinal rows and progressively evolved into circumferentially oriented bands located above muscle sarcomeres. VAB-10A was also detected basally and apically in the pharynx and along mechanosensory axons. VAB-10B was also present in the pharynx lumen, intestine lumen, nerve ring, and in body wall muscles and somatic gonad of larvae. The circumferential bands formed by VAB-10A matched those formed by IFs at all stages. VAB-10A staining strictly colocalized with myotactin in adults, but only partially in young larvae. The parallel bands formed by VAB-10B are interspersed with those formed by VAB-10A and extend beyond the area of muscle epidermis contact. The VAB-10B bands corresponded to the regularly spaced shallow furrows that pattern the cuticle and separate annuli ridges. Immunoelectron microscopy confirmed that VAB-10A (but not VAB-10B) is restricted to FOs. VAB-10A was exclusively detected in the epidermis in areas dense in filaments, a characteristic of FOs. Using the VAB-10B K22 antibodies, gold particles were observed in the epidermis adjacent to body wall muscles and in sarcomeres. Although the number of particles is low, quantitative analysis indicates that staining is specific. Thus, VAB-10B appears to have a disperse distribution in the epidermis and muscles.
    Expr16292   Using CRISPR-Cas9, we inserted a fluorescent tag at the endogenous locus encoding VAB-10B, PAR-1, SMA-1, EPS-8A, and H24G06.1, an uncharacterized protein. We found that, like PTRN-1, all five proteins localized to the apical membranes of the embryonic intestine.
    Expr12099   vab-10a is enriched at the invasive cell membrane of the anchor cell.
    Expr1035011 Tiling arrays expression graphs  
    Expr1020598 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012  
    Expr15944   VAB-10::GFP was present along apical membranes of all vulva cells throughout L4 morphogenesis.
    Expr1023557 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012  
    Expr1155867 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015  
    Expr1155865 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/hashimshony2015  
    Expr16323 SPC-1::GFP outlined all 7 vulval rings and was present near apical (luminal) membranes and also at sites of cell-cell contact (basolateral membranes). In contrast, UNC-70::GFP was present only at basolateral membranes, while SMA-1::GFP was present only at apical membranes. We showed previously that the spectrin-related protein VAB-10a/spectraplakin also localizes apically in the vulva (Cohen et al. 2020)  
    Expr2017945 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr1013098 Developmental gene expression time-course. Raw data can be downloaded from ftp://caltech.wormbase.org/pub/wormbase/datasets-published/levin2012  
    Expr2005756 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr2005755 Single cell embryonic expression. Only cell types with an expression fraction of greater 0.2 of the maximum expressed fraction are labeled (Full data can be downloaded from http://caltech.wormbase.org/pub/wormbase/datasets-published/packer2019/). The colors represent the broad cell class to which the cell type has been assigned. The size of the point is proportional to the log2 of the numbers of cells in the dataset of that cell type. Interactive visualizations are available as a web app (https://cello.shinyapps.io/celegans/) and can also be installed as an R package (https://github.com/qinzhu/VisCello.celegans).  
    Expr16297   VAB-10B nor WDR-62 localized to centrosomes of the early embryo or in dividing intestinal precursor cells but rather localized during intestinal cell polarization to the apical non-centrosomal microtubule-organizing center (ncMTOC). VAB-10B and WDR-62 localized to the apical surfaces of other epithelial cell types as indicated by colocalization with the conserved apical polarity protein PAR-3/PAR3.
    Expr13689   F-actin in the embryonic intestine becomes progressively enriched at the apical membrane and reduced in the cytoplasm during the time when apical junctions are forming and maturing.

24 GO Annotation

Annotation Extension Qualifier
  located_in
  located_in
  involved_in
  enables
  enables
  enables
  enables
  enables
  located_in
  located_in
  located_in
  located_in
  involved_in
  involved_in
  involved_in
  involved_in
  located_in
  located_in
  located_in
  located_in
  located_in
  located_in
  located_in
  located_in

7 Homologues

Type
orthologue
orthologue
orthologue
least diverged orthologue
least diverged orthologue
least diverged orthologue
least diverged orthologue

1 Locations


Feature . Primary Identifier
Start End Strand
WBGene00006876 11747424 11804991 -1

24 Ontology Annotations

Annotation Extension Qualifier
  located_in
  located_in
  involved_in
  enables
  enables
  enables
  enables
  enables
  located_in
  located_in
  located_in
  located_in
  involved_in
  involved_in
  involved_in
  involved_in
  located_in
  located_in
  located_in
  located_in
  located_in
  located_in
  located_in
  located_in

0 Regulates Expr Cluster

1 Sequence

Length
57568

1 Sequence Ontology Term